Medical and Surgical Treatment of Reproductive Outcomes in Polycystic Ovary Syndrome: An Overview of Systematic Reviews

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Gadalla Moustafa A.; Norman Robert J.; FRANZCOG -; Tay Chau T.; Hiam Danielle S.; Melder Angela; Pundir Jyotsna; Thangaratinam Shakila; Teede Helena J.; MOL BEN W.J.; Moran Lisa J.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: International Journal of Fertility & Sterility Year:2020 | Volume:13 | Issue:4 Page(s): 257-270

Download Full-Text

View:

400

Download:

258

Cites:

Information Journal Paper

Title

Medical and Surgical Treatment of Reproductive Outcomes in Polycystic Ovary Syndrome: An Overview of Systematic Reviews

Author(s)

Keywords

Infertility

Polycystic Ovary Syndrome

Review

Therapeutics

Treatment Outcome

Abstract

Polycystic Ovary Syndrome (PCOS) is a common, complex condition that affects up to 18% of reproductiveaged women, causing reproductive, metabolic and psychological dysfunctions. We performed an overview and appraisal of methodological quality of systematic Reviews that assessed medical and surgical treatments for reproductive outcomes in women with PCOS. Databases (MEDLINE, EMBASE, CINAHL PLUS and PROSPERO) were searched on the 15th of September 2017. We included any systematic Review that assessed the effect of medical or surgical management of PCOS on reproductive, pregnancy and neonatal outcomes. Eligibility assessment, data extraction and quality assessment by the Assessing the Methodological Quality of Systematic Reviews (AMSTAR) tool were performed in duplicate. We identified 53 Reviews comprising 44 Reviews included in this overview; the majority were moderate to high quality. In unselected women with PCOS, letrozole was associated with a higher live birth rate than clomiphene citrate (CC), while CC was better than metformin or placebo. In women with CC-resistant PCOS, gonadotrophins were associated with a higher live birth rate than CC plus metformin, which was better than laparoscopic ovarian drilling (LOD). LOD was associated with lower multiple pregnancy rates than other medical treatments. In women with PCOS undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), the addition of metformin to gonadotrophins resulted in less ovarian hyperstimulation syndrome (OHSS), and higher pregnancy and live birth rates than gonadotrophins alone. Gonadotrophin releasing hormone (GnRH) antagonist was associated with less OHSS, gonadotrophin units and shorter stimulation length than GnRH agonist. Letrozole appears to be a good first line treatment and gonadotrophins, as a second line treatment, for anovulatory women with PCOS. LOD results in lower multiple pregnancy rates. However, due to the heterogeneous nature of the included populations of women with PCOS, further larger scale trials are needed with more precise assessment of treatments according to heterogeneous variants of PCOS.

Cites

A Histomorphological Comparative Effects of Metformin, Pioglitazone, Repaglinide and Acarbose on Polycystic Ovary in Mice

References

Cite

APA: Copy

Gadalla, Moustafa A., Norman, Robert J., FRANZCOG, -, Tay, Chau T., Hiam, Danielle S., Melder, Angela, Pundir, Jyotsna, Thangaratinam, Shakila, Teede, Helena J., MOL, BEN W.J., & Moran, Lisa J.. (2020). Medical and Surgical Treatment of Reproductive Outcomes in Polycystic Ovary Syndrome: An Overview of Systematic Reviews. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 13(4), 257-270. SID. https://sid.ir/paper/306062/en

Vancouver: Copy

Gadalla Moustafa A., Norman Robert J., FRANZCOG -, Tay Chau T., Hiam Danielle S., Melder Angela, Pundir Jyotsna, Thangaratinam Shakila, Teede Helena J., MOL BEN W.J., Moran Lisa J.. Medical and Surgical Treatment of Reproductive Outcomes in Polycystic Ovary Syndrome: An Overview of Systematic Reviews. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2020;13(4):257-270. Available from: https://sid.ir/paper/306062/en

IEEE: Copy

Moustafa A. Gadalla, Robert J. Norman, - FRANZCOG, Chau T. Tay, Danielle S. Hiam, Angela Melder, Jyotsna Pundir, Shakila Thangaratinam, Helena J. Teede, BEN W.J. MOL, and Lisa J. Moran, “Medical and Surgical Treatment of Reproductive Outcomes in Polycystic Ovary Syndrome: An Overview of Systematic Reviews,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 13, no. 4, pp. 257–270, 2020, [Online]. Available: https://sid.ir/paper/306062/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops