MOLECULAR ASPECTS OF HEPATOCELLULAR CARCINOMA CAUSED BY HEPATITIS C VIRUS

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KARAMI A.; ALAVIAN S.M.; NAJAFI A.; HOSSEINI M.J.

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Journal Paper

Paper Information

Journal: Hepatitis Monthly Year:2006 | Volume:6 | Issue:2 Page(s): 75-82

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Title

MOLECULAR ASPECTS OF HEPATOCELLULAR CARCINOMA CAUSED BY HEPATITIS C VIRUS

Author(s)

KARAMI A. | ALAVIAN S.M. | NAJAFI A. | HOSSEINI M.J. | Issue Writer Certificate

Keywords

HEPATITIS C VIRUS (HCV)

HEPATOCELLULAR CARCINOMA

GENOMIC AND PROTEOMICS

Abstract

The hepatitis C virus (HCV) is a small, enveloped, single-stranded positive-sense RNA virus with a diameter of about 50 nm belonging to the Hepacivirus genus of the family Flaviviridae. The HCV genome is translated to produce a single protein of around 3011 amino acids. This "polyprotein" is then proteolytically processed by viral and cellular proteases to produce structural (core protein, envelope glycoproteins E1 and E2, ARFP/F protein, p7) and nonstructural (NS2-3 autoprotease, NS3-4A, NS4B, NS5A, NS5B) proteins. HEPATOCELLULAR CARCINOMA (HCC) is one of the most frequent malignant tumors worldwide, with increasing incidence. It is estimated that approximately 300-400 thousands of people in the IRAN and 4 million in the United States are persistently infected. It is important for tumor control to identify the factors that predispose patients to death. A large number of molecular factors have been shown to associate with the invasiveness of HCC, and have potential prognostic significance.

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APA: Copy

KARAMI, A., ALAVIAN, S.M., NAJAFI, A., & HOSSEINI, M.J.. (2006). MOLECULAR ASPECTS OF HEPATOCELLULAR CARCINOMA CAUSED BY HEPATITIS C VIRUS. HEPATITIS MONTHLY, 6(2), 75-82. SID. https://sid.ir/paper/306107/en

Vancouver: Copy

KARAMI A., ALAVIAN S.M., NAJAFI A., HOSSEINI M.J.. MOLECULAR ASPECTS OF HEPATOCELLULAR CARCINOMA CAUSED BY HEPATITIS C VIRUS. HEPATITIS MONTHLY[Internet]. 2006;6(2):75-82. Available from: https://sid.ir/paper/306107/en

IEEE: Copy

A. KARAMI, S.M. ALAVIAN, A. NAJAFI, and M.J. HOSSEINI, “MOLECULAR ASPECTS OF HEPATOCELLULAR CARCINOMA CAUSED BY HEPATITIS C VIRUS,” HEPATITIS MONTHLY, vol. 6, no. 2, pp. 75–82, 2006, [Online]. Available: https://sid.ir/paper/306107/en

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