ACUTE EXACERBATIONS OF CHRONIC HEPATITIS B ARE ACCOMPANIED BY DECLINE OF CORE ANTIGEN-SPECIFIC REGULATORY T-CELL FREQUENCIES: IMPLICATIONS FOR SUCCESSFUL ANTI-HBV TREATMENTS

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TSAI S.L.; WANG S.L.; FENG I.C.; KUO H.T.; KOAY L.B.; SHEU M.J.; LEE CHUAN; SUN C.S.; WU K.T.; LIN CH.Y.

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Journal Paper

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Journal: Hepatitis Monthly Year:2007 | Volume:7 | Issue:4 Page(s): 183-200

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Title

ACUTE EXACERBATIONS OF CHRONIC HEPATITIS B ARE ACCOMPANIED BY DECLINE OF CORE ANTIGEN-SPECIFIC REGULATORY T-CELL FREQUENCIES: IMPLICATIONS FOR SUCCESSFUL ANTI-HBV TREATMENTS

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Keywords

CHRONIC HEPATITIS B

ACUTE EXACERBATION

REGULATORY T CELL

SUSTAINED REMISSION

Abstract

Background and Aims: ACUTE EXACERBATIONs (AEs) of perinatally-acquired CHRONIC HEPATITIS B (CHB) are accompanied by increased T cell responses to hepatitis B core and e antigens (HBcAg & HBeAg). Naturally-arising forkhead transcription factor Foxp3 (forkhead box p3)-expressing CD4+CD25+ regulatory T (Treg) cells are thought to be important in the control of infectious diseases. This study aimed to investigate whether HBcAg-specific Treg cells play a role in modulating spontaneous AEs and in influencing the outcome of anti-hepatitis B virus (HBV) treatments. Methods: The SYFPEITHI scoring system was employed to predict epitope peptides on HBcAg overlapping with HBeAg for the construction of peptide-HLA class II tetramers to measure HBcAg-specific Treg cell frequencies (Treg f). Results: HBcAg-specific Treg f declined significantly in association with increased HBcAg-specific cytotoxic T lymphocyte frequencies during spontaneous AEs without treatment. Vigorous in vitro expansion of CD4+CD25+Treg cells from CHB patients responding to HBcAg and/or its peptides plus interleukin-2 (IL-2) was consistently detected. Depletion of Treg cells from peripheral blood mononuclear cells enhanced proliferation to HBcAg. In contrast, patients with AEs who received anti-HBV treatments with oral nucleoside analogues or interferon-alpha injection revealed that more post treatment increase of HBcAg-specific Treg f correlated with a higher SUSTAINED REMISSION rate to the therapy. Conclusions: These data indicate that HBcAg-specific Treg cells from perinatally-acquired CHB patients are proliferative to HBcAg and its peptides and exhibit suppressor activity. They play a crucial role in modulating spontaneous AEs and in successful anti-HBV treatments.

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APA: Copy

TSAI, S.L., WANG, S.L., FENG, I.C., KUO, H.T., KOAY, L.B., SHEU, M.J., LEE, CHUAN, SUN, C.S., WU, K.T., & LIN, CH.Y.. (2007). ACUTE EXACERBATIONS OF CHRONIC HEPATITIS B ARE ACCOMPANIED BY DECLINE OF CORE ANTIGEN-SPECIFIC REGULATORY T-CELL FREQUENCIES: IMPLICATIONS FOR SUCCESSFUL ANTI-HBV TREATMENTS. HEPATITIS MONTHLY, 7(4), 183-200. SID. https://sid.ir/paper/306149/en

Vancouver: Copy

TSAI S.L., WANG S.L., FENG I.C., KUO H.T., KOAY L.B., SHEU M.J., LEE CHUAN, SUN C.S., WU K.T., LIN CH.Y.. ACUTE EXACERBATIONS OF CHRONIC HEPATITIS B ARE ACCOMPANIED BY DECLINE OF CORE ANTIGEN-SPECIFIC REGULATORY T-CELL FREQUENCIES: IMPLICATIONS FOR SUCCESSFUL ANTI-HBV TREATMENTS. HEPATITIS MONTHLY[Internet]. 2007;7(4):183-200. Available from: https://sid.ir/paper/306149/en

IEEE: Copy

S.L. TSAI, S.L. WANG, I.C. FENG, H.T. KUO, L.B. KOAY, M.J. SHEU, CHUAN LEE, C.S. SUN, K.T. WU, and CH.Y. LIN, “ACUTE EXACERBATIONS OF CHRONIC HEPATITIS B ARE ACCOMPANIED BY DECLINE OF CORE ANTIGEN-SPECIFIC REGULATORY T-CELL FREQUENCIES: IMPLICATIONS FOR SUCCESSFUL ANTI-HBV TREATMENTS,” HEPATITIS MONTHLY, vol. 7, no. 4, pp. 183–200, 2007, [Online]. Available: https://sid.ir/paper/306149/en

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