THYROID DYSFUNCTION IN PATIENTS WITH CHRONIC VIRAL HEPATITIS B AND C DURING ALPHA INTERFERON THERAPY

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ZIAEI AMIR; ESFAHANIAN F.; ALAVIAN S.M.; SARRESHTEHDARI M.

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Journal Paper

Paper Information

Journal: Hepatitis Monthly Year:2009 | Volume:9 | Issue:2 (23) Page(s): 110-113

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Title

THYROID DYSFUNCTION IN PATIENTS WITH CHRONIC VIRAL HEPATITIS B AND C DURING ALPHA INTERFERON THERAPY

Author(s)

ZIAEI AMIR | ESFAHANIAN F. | ALAVIAN S.M. | SARRESHTEHDARI M. | Issue Writer Certificate

Keywords

INTERFERON ALFA

THYROID

HEPATITIS B

HEPATITIS C

Abstract

Background and Aims: THYROID dysfunction has been reported in patients with chronic viral HEPATITIS B and C before and after alpha interferon (IFN-a) therapy and a high prevalence of anti HEPATITIS C virus (anti-HCV) antibodies in patients with autoimmune THYROIDitis has been shown. The aim of this study was to determine the rate of THYROID dysfunction in HEPATITIS B virus (HBV) and HCV infected patients during IFN-α| therapy and to compare them.Methods: In this prospective study, many patients with HEPATITIS B and C who had undergone IFN-a therapy were studied. Eighteen cases of HBV and fifty-eight cases of HCV entered the study. THYROID weight measurement, THYROID functional test and anti-thyroid antibodies assay were performed when the study initiated and were repeated after two, four and six months.Results: THYROID dysfunction was not seen in the HBV group. Only 6 (10.3%) cases of THYROID dysfunction were seen in HCV group (5 hypothyroidism and 1 THYROIDitis). Four cases of them had positive levels of THYROID peroxidase antibody (Tpo Ab) before IFN-α| therapy. In the HBV group, only 1 (5.5%) patient had positive levels of Tpo Ab. However, at the end of the study, 3 (16.7%) patients had positive levels of Tpo Ab. In the HCV group, at the beginning of the treatment, 8 (13.8%) patients had Tpo Ab; but at the end of study, 14 (24.1%) cases became positive. During the IFN-a therapy, mean weight of THYROID gland in both HCV and HBV groups were significantly increased (P<0.005 and P<0.001 respectively). There were not any relationships between thyroglobulin (Tg) Ab levels and duration of IFN-a therapy. Conclusions: Patients with HCV are more susceptible to THYROID dysfunction during IFN-a therapy than patients with HBV. As a result, screening of THYROID gland function and Tpo Ab titers in all patients with HCV before and during IFN- a therapy may be necessary. However, this needs further studies in HBV patients.

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APA: Copy

ZIAEI, AMIR, ESFAHANIAN, F., ALAVIAN, S.M., & SARRESHTEHDARI, M.. (2009). THYROID DYSFUNCTION IN PATIENTS WITH CHRONIC VIRAL HEPATITIS B AND C DURING ALPHA INTERFERON THERAPY. HEPATITIS MONTHLY, 9(2 (23)), 110-113. SID. https://sid.ir/paper/306224/en

Vancouver: Copy

ZIAEI AMIR, ESFAHANIAN F., ALAVIAN S.M., SARRESHTEHDARI M.. THYROID DYSFUNCTION IN PATIENTS WITH CHRONIC VIRAL HEPATITIS B AND C DURING ALPHA INTERFERON THERAPY. HEPATITIS MONTHLY[Internet]. 2009;9(2 (23)):110-113. Available from: https://sid.ir/paper/306224/en

IEEE: Copy

AMIR ZIAEI, F. ESFAHANIAN, S.M. ALAVIAN, and M. SARRESHTEHDARI, “THYROID DYSFUNCTION IN PATIENTS WITH CHRONIC VIRAL HEPATITIS B AND C DURING ALPHA INTERFERON THERAPY,” HEPATITIS MONTHLY, vol. 9, no. 2 (23), pp. 110–113, 2009, [Online]. Available: https://sid.ir/paper/306224/en

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