POLYMORPHISMS WITHIN FAS GENE ARE NOT ASSOIATED WITH OCCULT HEPATITIS B VIRUS INFECTION

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ARABABADI M.K.; MOHAMMADZADEH ADEL; POURFATH ELAH A.A.; KENNEDY D.

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Paper Information

Journal: Hepatitis Monthly Year:2011 | Volume:11 | Issue:1 (30) Page(s): 23-26

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Title

POLYMORPHISMS WITHIN FAS GENE ARE NOT ASSOIATED WITH OCCULT HEPATITIS B VIRUS INFECTION

Author(s)

ARABABADI M.K. | MOHAMMADZADEH ADEL | POURFATH ELAH A.A. | KENNEDY D. | Issue Writer Certificate

Keywords

HEPATITIS B INFECTION

FAS

POLYMORPHISM

HBSAG

HBV

DNA

Abstract

Background: Occult HEPATITIS B INFECTION (OBI) is a form of hepatitis in which there is an absence of detectable HBSAG, despite the presence of HBV-DNA in the peripheral blood of patients. It seems that non-effective or attenuated immune system responses against HBV lead to the development of OBI. Previous studies showed that the FAS/Fas ligand (FasL) system is an important death signaling pathway that is used by cytotoxic T lymphocytes to eradicate HBV from the liver.Objectives: To investigate POLYMORPHISMs in the -670 region of the FAS gene in those with OBI. Patients and Methods: The plasma samples from 3700 blood donors were tested for HBSAG and anti- HBs by ELISA. The HBSAG-/anti-HBc+ samples were selected and screened for HBV-DNA by PCR. Those with HBV-DNA were diagnosed as OBI and PCR-RFLP technique was performed to examine POLYMORPHISMs within their FAS gene.Results: 352 (9.5%) of 3700 blood samples were HBSAG-/anti-HBc+. HBV-DNA was detected in 57 (16.1%) of 352 HBSAG-/anti-HBc+ samples. Therefore, 57 HBSAG-/anti-HBc+/HBV-DNA+ patients were diagnosed as OBI. Patient and control groups had no significant differences in terms of the studied POLYMORPHISMs. onclusions: The functional POLYMORPHISMs in the promoter region of FAS gene are not associated with OBI. Therefore, it may be concluded that POLYMORPHISMs at the-670 position of the FAS gene do not have any critical effects on the immune response against HBV in OBI.

Cites

MOLECULAR CHARACTERIZATION OF PRE-CORE/CORE AND S REGION OF HEPATITIS B VIRUS IN HEMODIALYSIS PATIENTS WITH OCCULT HEPATITIS B INFECTION

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APA: Copy

ARABABADI, M.K., MOHAMMADZADEH, ADEL, POURFATH ELAH, A.A., & KENNEDY, D.. (2011). POLYMORPHISMS WITHIN FAS GENE ARE NOT ASSOIATED WITH OCCULT HEPATITIS B VIRUS INFECTION. HEPATITIS MONTHLY, 11(1 (30)), 23-26. SID. https://sid.ir/paper/306336/en

Vancouver: Copy

ARABABADI M.K., MOHAMMADZADEH ADEL, POURFATH ELAH A.A., KENNEDY D.. POLYMORPHISMS WITHIN FAS GENE ARE NOT ASSOIATED WITH OCCULT HEPATITIS B VIRUS INFECTION. HEPATITIS MONTHLY[Internet]. 2011;11(1 (30)):23-26. Available from: https://sid.ir/paper/306336/en

IEEE: Copy

M.K. ARABABADI, ADEL MOHAMMADZADEH, A.A. POURFATH ELAH, and D. KENNEDY, “POLYMORPHISMS WITHIN FAS GENE ARE NOT ASSOIATED WITH OCCULT HEPATITIS B VIRUS INFECTION,” HEPATITIS MONTHLY, vol. 11, no. 1 (30), pp. 23–26, 2011, [Online]. Available: https://sid.ir/paper/306336/en

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