ROSUVASTATIN REDUCES NONALCOHOLIC FATTY LIVER DISEASE IN PATIENTS WITH CHRONIC HEPATITIS C TREATED WITH α-INTERFERON AND RIBAVIRIN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MALAGUARNERA M.; VACANTE M.; RUSSO C.; GARGANTE M.P.; GIORDANO M.; BERTINO G.; NERI S.; MALAGUARNERA MARIANO; GALVANO F.; VOLTI G.L.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Hepatitis Monthly Year:2011 | Volume:11 | Issue:2 (31) Page(s): 92-98

Download Full-Text

View:

423

Download:

279

Cites:

Information Journal Paper

Title

ROSUVASTATIN REDUCES NONALCOHOLIC FATTY LIVER DISEASE IN PATIENTS WITH CHRONIC HEPATITIS C TREATED WITH α-INTERFERON AND RIBAVIRIN

Author(s)

Keywords

NAFLD

RIBAVIRIN

INTERFERON

HEPATITIS

Abstract

Background: Nonalcoholic fatty liver disease develops in patients with chronic HEPATITIS C. INTERFERON and RIBAVIRIN combination therapy is the standard treatment for chronic HEPATITIS C, but if present, NAFLD can reduce the virological response to anti-HCV therapies. Objectives: We determined whether the addition of rosuvastatin to INTERFERON and RIBAVIRIN improves the sustained virological response (SVR) and reduces steatosis.Patients and Methods: This study was a prospective, randomized, open-label trial. Between January 2004 and December 2007, 65 patients with chronic HEPATITIS (27 women and 38 men, mean age 48 years) aged 32-63 years (median 46 years) were consecutively enrolled. Patients were randomly assigned to receive leukocyte INTERFERON alpha (3 MIU 3 times per week) plus RIBAVIRIN (1200 mg per day) for 12 months or INTERFERON alpha and RIBAVIRIN at the same dosages plus rosuvastatin (5 mg per day). The primary endpoints were measurements in SVR, liver enzyme, cholesterol, triglyceride, CRP, glucose, and insulin levels; and Homa-IR, fibrosis, and steatosis scores.Results: After 12 months of treatment, we observed a significant improvement in SVR in 51% of patients who received INTERFERON plus RIBAVIRIN plus rosuvastatin compared with 18% of relapsers (OR 1.52; 95% CI= 0.41-5.64; RR 1.13). There were 23 responders (69%) and 10 nonresponders (30%) (OR 1.38; 95% CI= 0.49-16.5; RR 1.11). When comparing INTERFERON plus RIBAVIRIN group vs INTERFERON plus RIBAVIRIN and rosuvastatin group after 12 months, we observed a significant difference in AST (85.70 vs.106.5.00 IU/ml) (OR 1.2; 95% CI= 0.29-4.94; RR 1.04; p<0.001), ALT (81.80 vs. 126.2 IU/ml) (OR 1.2; 95% CI= 0.29-4.94; RR 1.04; p<0.001), LDL-cholesterol (0.01 vs. 0.60 mmol/l) (OR 14; 95% CI= 3.98-49.16; p RR 2.96; <0.001), triglycerides (0.17 vs. 0.2 mmol/l) (OR 20; 95% CI= 4.94-80.89; RR 5.38; p<0.05), and Viremia (1.8 vs. 2.48 UI/ml, p<0.05). Mean fibrosis score decreased 0.10 vs. 0.50 (OR 4.5; 95% CI= 0.89-22.66; RR 1.5; p<0.05), and mean steatosis score declined 0.30 vs. 0.50 (OR 11.2; CI= 2.88-43.53; RR 2.75; p<0.001).Conclusions: In HCV patients with NAFLD, the addition of rosuvastatin to INTERFERON and RIBAVIRIN significantly reduces viremia, steatosis, and fibrosis without causing side effects.

Cites

No record.

References

No record.

Cite

APA: Copy

MALAGUARNERA, M., VACANTE, M., RUSSO, C., GARGANTE, M.P., GIORDANO, M., BERTINO, G., NERI, S., MALAGUARNERA, MARIANO, GALVANO, F., & VOLTI, G.L.. (2011). ROSUVASTATIN REDUCES NONALCOHOLIC FATTY LIVER DISEASE IN PATIENTS WITH CHRONIC HEPATITIS C TREATED WITH α-INTERFERON AND RIBAVIRIN. HEPATITIS MONTHLY, 11(2 (31)), 92-98. SID. https://sid.ir/paper/306344/en

Vancouver: Copy

MALAGUARNERA M., VACANTE M., RUSSO C., GARGANTE M.P., GIORDANO M., BERTINO G., NERI S., MALAGUARNERA MARIANO, GALVANO F., VOLTI G.L.. ROSUVASTATIN REDUCES NONALCOHOLIC FATTY LIVER DISEASE IN PATIENTS WITH CHRONIC HEPATITIS C TREATED WITH α-INTERFERON AND RIBAVIRIN. HEPATITIS MONTHLY[Internet]. 2011;11(2 (31)):92-98. Available from: https://sid.ir/paper/306344/en

IEEE: Copy

M. MALAGUARNERA, M. VACANTE, C. RUSSO, M.P. GARGANTE, M. GIORDANO, G. BERTINO, S. NERI, MARIANO MALAGUARNERA, F. GALVANO, and G.L. VOLTI, “ROSUVASTATIN REDUCES NONALCOHOLIC FATTY LIVER DISEASE IN PATIENTS WITH CHRONIC HEPATITIS C TREATED WITH α-INTERFERON AND RIBAVIRIN,” HEPATITIS MONTHLY, vol. 11, no. 2 (31), pp. 92–98, 2011, [Online]. Available: https://sid.ir/paper/306344/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops