مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

THE DIFFERENCES IN GENE EXPRESSION PROFILE INDUCED BY GENOTYPE 1B HEPATITIS C VIRUS CORE ISOLATED FROM LIVER TUMOR AND ADJACENT NON-TU-MORAL TISSUE

Pages

  255-262

Abstract

 Background: Core protein of the HEPATITIS C VIRUS (HCV) has an important role in HCV self-replication, pathogenesis and carcinogenesis.Objectives: To identify the effect of core proteins from different quasispecies of HCV genotype 1b expressed in a HepG2 cell line on human GENE EXPRESSION profiles.Materials and Methods: Core protein eukrocytic expression plasmids (pEGFP-N1) containing different quasispecie core protein genes of GENOTYPES 1b HCV derived from of HCV-related hepatocellular carcinoma (HCC) tumoral tissue (T) and non-tumoral tissue (NT) were constructed and then transfected to HepG2 cell line. The GENE EXPRESSION spectrum in the cell expression core proteins from T and NT were compared with those in the control by Affymetrix human genome HG-U 133 plus 2.0 microarray.Results: Different GENE EXPRESSION profiles were acquired between HepG2 expressing core proteins derived from T and NT tissues. Both core proteins caused the modulation of several genes that are up/down-regulated as compared to control, including genes involved in oncogenesis, signal transduction, cell apoptosis, and cell growth cycle regulation. Surprisingly, only one gene-CSNK1A1-was up-regulated by both T and NT core variants.Conclusions: Core proteins isolated from tumoral or non-tumoral nodules mediate expression of different cellular genes suggesting that variants isolated from different quasispecies may have different biological effects.

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    APA: Copy

    YAN, XUE BING, CHEN, ZHI, & BRECHOT, CHRISTIAN. (2011). THE DIFFERENCES IN GENE EXPRESSION PROFILE INDUCED BY GENOTYPE 1B HEPATITIS C VIRUS CORE ISOLATED FROM LIVER TUMOR AND ADJACENT NON-TU-MORAL TISSUE. HEPATITIS MONTHLY, 11(4 (33)), 255-262. SID. https://sid.ir/paper/306382/en

    Vancouver: Copy

    YAN XUE BING, CHEN ZHI, BRECHOT CHRISTIAN. THE DIFFERENCES IN GENE EXPRESSION PROFILE INDUCED BY GENOTYPE 1B HEPATITIS C VIRUS CORE ISOLATED FROM LIVER TUMOR AND ADJACENT NON-TU-MORAL TISSUE. HEPATITIS MONTHLY[Internet]. 2011;11(4 (33)):255-262. Available from: https://sid.ir/paper/306382/en

    IEEE: Copy

    XUE BING YAN, ZHI CHEN, and CHRISTIAN BRECHOT, “THE DIFFERENCES IN GENE EXPRESSION PROFILE INDUCED BY GENOTYPE 1B HEPATITIS C VIRUS CORE ISOLATED FROM LIVER TUMOR AND ADJACENT NON-TU-MORAL TISSUE,” HEPATITIS MONTHLY, vol. 11, no. 4 (33), pp. 255–262, 2011, [Online]. Available: https://sid.ir/paper/306382/en

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