مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

THE IMPACT OF HEPATITIS C VIRUS INFECTION ON KIDNEY TRANSPLANTATION OUTCOMES: A SYSTEMATIC REVIEW OF 18 OBSERVATIONAL STUDIES

Pages

  247-254

Abstract

 Background: Hepatitis C virus (HCV) infection occurs in 0% to 51% of dialysis patients, and many HCV-positive patients are urged to undergo KIDNEY TRANSPLANTATION. However, the outcome of renal transplantation in HCV-positive recipients is unknown.Objectives: Our review aimed to address the outcomes of renal transplantation recipients (RTRs) following KIDNEY TRANSPLANTATION.Materials and Methods: We selected studies that used the adjusted relative risk (aRR) and 95% CI of all-cause MORTALITY and graft loss in HCV-positive compared with HCV-negative RTRs as study endpoints. Cox proportional hazard analysis was used in all studies to calculate the independent effects of HCV infection on RTR outcomes. Sixteen retrospective cohort studies and 2 clinical trials were selected for our review. Sixteen studies were related to PATIENT SURVIVAL, and 12 examined GRAFT SURVIVAL.Results: The combined hazard ratio in HCV-infected recipients was 1.69-fold (1.33-1.97, p<0.0001) and 1.56 times (1.22-2.004, p<0.0001) greater than that of HCV-negative recipients for MORTALITY and graft loss, respectively.Conclusions: Although HCV-infected RTRs have worse outcomes than HCV-negative RTRs, KIDNEY TRANSPLANTATION is the preferred treatment for patients with HCV infection and end-stage renal disease.

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    APA: Copy

    ROSTAMI, ZOHREH, NOURBALA, MOHAMMAD HOSSIEN, ALAVIAN, SEYED MOAYED, BIERAGHDAR, FATEMEH, JAHANI, YUNES, & EINOLLAHI, BEHZAD. (2011). THE IMPACT OF HEPATITIS C VIRUS INFECTION ON KIDNEY TRANSPLANTATION OUTCOMES: A SYSTEMATIC REVIEW OF 18 OBSERVATIONAL STUDIES. HEPATITIS MONTHLY, 11(4 (33)), 247-254. SID. https://sid.ir/paper/306385/en

    Vancouver: Copy

    ROSTAMI ZOHREH, NOURBALA MOHAMMAD HOSSIEN, ALAVIAN SEYED MOAYED, BIERAGHDAR FATEMEH, JAHANI YUNES, EINOLLAHI BEHZAD. THE IMPACT OF HEPATITIS C VIRUS INFECTION ON KIDNEY TRANSPLANTATION OUTCOMES: A SYSTEMATIC REVIEW OF 18 OBSERVATIONAL STUDIES. HEPATITIS MONTHLY[Internet]. 2011;11(4 (33)):247-254. Available from: https://sid.ir/paper/306385/en

    IEEE: Copy

    ZOHREH ROSTAMI, MOHAMMAD HOSSIEN NOURBALA, SEYED MOAYED ALAVIAN, FATEMEH BIERAGHDAR, YUNES JAHANI, and BEHZAD EINOLLAHI, “THE IMPACT OF HEPATITIS C VIRUS INFECTION ON KIDNEY TRANSPLANTATION OUTCOMES: A SYSTEMATIC REVIEW OF 18 OBSERVATIONAL STUDIES,” HEPATITIS MONTHLY, vol. 11, no. 4 (33), pp. 247–254, 2011, [Online]. Available: https://sid.ir/paper/306385/en

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