IL28B SNP GENOTYPING AMONG IRANIAN HCV-INFECTED PATIENTS: A PRELIMINARY REPORT (LETTER TO EDITOR)

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MAHBOOBI NASTARAN; BEHNAVA BITA; ALAVIAN SEYED MOAYED

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Journal Paper

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Journal: Hepatitis Monthly Year:2011 | Volume:11 | Issue:5 (34) Page(s): 386-387

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Information Journal Paper

Title

IL28B SNP GENOTYPING AMONG IRANIAN HCV-INFECTED PATIENTS: A PRELIMINARY REPORT (LETTER TO EDITOR)

Author(s)

MAHBOOBI NASTARAN | BEHNAVA BITA | ALAVIAN SEYED MOAYED | Issue Writer Certificate

Keywords

IL28B

GENOTYPE

HEPATITIS C VIRUS

IRAN

Abstract

At the beginning of the third millennium, HEPATITIS C VIRUS (HCV) infection continues to be a major health hazard, with 170 million chronically infected people worldwide (1). Recent research has found that the prevalence of HCV infection in IRAN is 1% and 0.1% in males and females, respectively (2). Although a combination of pegylated interferon (PEG-IFN) and ribavirin (RBV) has been established as a standard anti-HCV therapy, treatment responses vary. Numerous factors, including gender, age, HCV RNA level prior to treatment, liver cirrhosis, and HCV GENOTYPEs have been determined to contribute to this discrepancy (1). In addition, a number of recently published, genome-wide association studies (GWAS) have shown that polymorphisms within the IL28B locus result in differences between patients’ responses to anti-HCV treatment (3-6). In this regard, rs8099917 (8 kb upstream of the IL28B gene) and rs12979860 (3 kb upstream of the IL28B gene) have been identified asrelevant single nucleotide polymorphisms (SNPs) that significantly impact treatment response to HCV infection (7). Although both SNPs are known to be independent predictors of response to anti-HCV therapy, a recent, extensive meta-analysis has reported that rs12979860 is more closely related to treatment responses (8). The prevalence of these SNPs and the rate of sustained viral response (SVR) have been found to vary across Caucasian, African American, and Japanese ethnicities (1).

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APA: Copy

MAHBOOBI, NASTARAN, BEHNAVA, BITA, & ALAVIAN, SEYED MOAYED. (2011). IL28B SNP GENOTYPING AMONG IRANIAN HCV-INFECTED PATIENTS: A PRELIMINARY REPORT (LETTER TO EDITOR). HEPATITIS MONTHLY, 11(5 (34)), 386-387. SID. https://sid.ir/paper/306395/en

Vancouver: Copy

MAHBOOBI NASTARAN, BEHNAVA BITA, ALAVIAN SEYED MOAYED. IL28B SNP GENOTYPING AMONG IRANIAN HCV-INFECTED PATIENTS: A PRELIMINARY REPORT (LETTER TO EDITOR). HEPATITIS MONTHLY[Internet]. 2011;11(5 (34)):386-387. Available from: https://sid.ir/paper/306395/en

IEEE: Copy

NASTARAN MAHBOOBI, BITA BEHNAVA, and SEYED MOAYED ALAVIAN, “IL28B SNP GENOTYPING AMONG IRANIAN HCV-INFECTED PATIENTS: A PRELIMINARY REPORT (LETTER TO EDITOR),” HEPATITIS MONTHLY, vol. 11, no. 5 (34), pp. 386–387, 2011, [Online]. Available: https://sid.ir/paper/306395/en

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