LIVER INJURY INDUCED BY HIGH-DOSE METHYLPREDNISOLONE THERAPY: A CASE REPORT AND BRIEF REVIEW OF THE LITERATURE

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GUTKOWSKI KRZYSZTOF; CHWIST ALINA; HARTLEB MAREK

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Journal: Hepatitis Monthly Year:2011 | Volume:11 | Issue:8 (37) Page(s): 656-661

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Title

LIVER INJURY INDUCED BY HIGH-DOSE METHYLPREDNISOLONE THERAPY: A CASE REPORT AND BRIEF REVIEW OF THE LITERATURE

Author(s)

GUTKOWSKI KRZYSZTOF | CHWIST ALINA | HARTLEB MAREK | Issue Writer Certificate

Keywords

METHYLPREDNISOLONE

HEPATOTOXICITY

ADVERSE DRUG REACTIONS

MULTIPLE SCLEROSIS

Abstract

Corticosteroids are used widely to treat many types of disease. In general, these drugs are considered safe for the liver; however, recent reports have demonstrated that highdose METHYLPREDNISOLONE (MT) may cause severe liver injury. Here, we report a case of a 24-year-old female who was given pulsed MT therapy for MULTIPLE SCLEROSIS. MT induced icteric hepatitis and impaired liver synthetic function. HEPATOTOXICITY developed several weeks after drug exposure, and the causal association with MT was confirmed by unintentional rechallenge test. A brief review of the literature on corticosteroid- induced HEPATOTOXICITY is presented.

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APA: Copy

GUTKOWSKI, KRZYSZTOF, CHWIST, ALINA, & HARTLEB, MAREK. (2011). LIVER INJURY INDUCED BY HIGH-DOSE METHYLPREDNISOLONE THERAPY: A CASE REPORT AND BRIEF REVIEW OF THE LITERATURE. HEPATITIS MONTHLY, 11(8 (37)), 656-661. SID. https://sid.ir/paper/306438/en

Vancouver: Copy

GUTKOWSKI KRZYSZTOF, CHWIST ALINA, HARTLEB MAREK. LIVER INJURY INDUCED BY HIGH-DOSE METHYLPREDNISOLONE THERAPY: A CASE REPORT AND BRIEF REVIEW OF THE LITERATURE. HEPATITIS MONTHLY[Internet]. 2011;11(8 (37)):656-661. Available from: https://sid.ir/paper/306438/en

IEEE: Copy

KRZYSZTOF GUTKOWSKI, ALINA CHWIST, and MAREK HARTLEB, “LIVER INJURY INDUCED BY HIGH-DOSE METHYLPREDNISOLONE THERAPY: A CASE REPORT AND BRIEF REVIEW OF THE LITERATURE,” HEPATITIS MONTHLY, vol. 11, no. 8 (37), pp. 656–661, 2011, [Online]. Available: https://sid.ir/paper/306438/en

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