THE CORRELATION OF IL28B GENOTYPE WITH SUSTAINED VIROLOGIC RESPONSE IN ROMANIAN PATIENTS WITH CHRONIC HEPATITIS C

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SPOREA IOAN; POPESCU ALINA; CURESCU MANUELA; SIRLI ROXANA; DAN ISABEL; GOLDIS ADRIAN; GRADINARU OANA; ARDELEAN MELANIA; DANILA MIRELA; KUBOTA S.; DELEANU ALEXANDRA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Hepatitis Monthly Year:2011 | Volume:11 | Issue:12 (41) Page(s): 975-979

Download Full-Text

View:

370

Download:

310

Cites:

Information Journal Paper

Title

THE CORRELATION OF IL28B GENOTYPE WITH SUSTAINED VIROLOGIC RESPONSE IN ROMANIAN PATIENTS WITH CHRONIC HEPATITIS C

Author(s)

Keywords

GENETIC VARIATION

IL28B PROTEIN

HUMAN

HEPATITIS C

CHRONIC

Abstract

Background: Multiple variables influencing the sustained virologic response (SVR) in CHRONIC HEPATITIS C have been evaluated. one of them is genetic polymorphism near the IL28B gene.Objectives: The aim of this study was to evaluate the influence of IL28B genotypes on SVR rates in a group of patients with CHRONIC HEPATITIS C from the western part of Romania.Patients and Methods: A retrospective study was performed in 107 consecutive patients, previously treated with standard-of-care medication for CHRONIC HEPATITIS C, identified from the databases of 2 centers. Patient demographics, viral load before treatment and at 12, 24, and 72 weeks from the treatment start, and IL28B genotype were evaluated.Results: Among the 107 patents in the study group, 54 patients had SVR (50.5%), and 62 (57.9%) showed a complete early virologic response (cEVR). The SVR rates according to IL28B genotype were as follows: 73.1% in patients with genotype C/C, 40.9% in those with genotype C/T, and 57.1% in those with genotype T/T (i.e., 73.1% among patients with the C/C genotypevs. 43.7% among those with non-C/C genotypes, P=0.0126). The ceVR rates were 80.8% in patients with the C/C genotypevs. 51.2% in those with non-C/C genotypes (P=0.011).Conclusions: In our cohort of 107 Caucasian HCV patients, the SVR rate was 50.5% with standard-of-care treatment. The SVR rate was directly related to the IL28B genotype: 73.1% in the C/C genotypevs. 43.7% in non-C/C genotypes (P=0.0126).

Cites

No record.

References

No record.

Cite

APA: Copy

SPOREA, IOAN, POPESCU, ALINA, CURESCU, MANUELA, SIRLI, ROXANA, DAN, ISABEL, GOLDIS, ADRIAN, GRADINARU, OANA, ARDELEAN, MELANIA, DANILA, MIRELA, KUBOTA, S., & DELEANU, ALEXANDRA. (2011). THE CORRELATION OF IL28B GENOTYPE WITH SUSTAINED VIROLOGIC RESPONSE IN ROMANIAN PATIENTS WITH CHRONIC HEPATITIS C. HEPATITIS MONTHLY, 11(12 (41)), 975-979. SID. https://sid.ir/paper/306493/en

Vancouver: Copy

SPOREA IOAN, POPESCU ALINA, CURESCU MANUELA, SIRLI ROXANA, DAN ISABEL, GOLDIS ADRIAN, GRADINARU OANA, ARDELEAN MELANIA, DANILA MIRELA, KUBOTA S., DELEANU ALEXANDRA. THE CORRELATION OF IL28B GENOTYPE WITH SUSTAINED VIROLOGIC RESPONSE IN ROMANIAN PATIENTS WITH CHRONIC HEPATITIS C. HEPATITIS MONTHLY[Internet]. 2011;11(12 (41)):975-979. Available from: https://sid.ir/paper/306493/en

IEEE: Copy

IOAN SPOREA, ALINA POPESCU, MANUELA CURESCU, ROXANA SIRLI, ISABEL DAN, ADRIAN GOLDIS, OANA GRADINARU, MELANIA ARDELEAN, MIRELA DANILA, S. KUBOTA, and ALEXANDRA DELEANU, “THE CORRELATION OF IL28B GENOTYPE WITH SUSTAINED VIROLOGIC RESPONSE IN ROMANIAN PATIENTS WITH CHRONIC HEPATITIS C,” HEPATITIS MONTHLY, vol. 11, no. 12 (41), pp. 975–979, 2011, [Online]. Available: https://sid.ir/paper/306493/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops