DUAL ROLE OF MIR-122 IN MOLECULAR PATHOGENESIS OF VIRAL HEPATITIS

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SENDI HOSSEIN

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Journal Paper

Paper Information

Journal: Hepatitis Monthly Year:2012 | Volume:12 | Issue:5 Page(s): 312-314

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Information Journal Paper

Title

DUAL ROLE OF MIR-122 IN MOLECULAR PATHOGENESIS OF VIRAL HEPATITIS

Author(s)

SENDI HOSSEIN | Issue Writer Certificate

Keywords

MICRO RNAS

HEPATOCYTE NUCLEAR FACTORS

CYCLIN G1

Abstract

The hepatic microRNA (miRNA), miR-122, is the most abundant miRNA within the liver, where it accounts for 70% of the total miRNA pool. It is known that miR-122, as an unusual host factor, increases the abundance of hepatitis C virus (HCV) RNA in HCV infection by binding directly to the 5’-UTR of the viral genome.Therefore, it has been suggested as a potential target for the treatment of hepatitis C. However, recent evidence shows that miR-122 decreases HBV replication through the inhibitory effect of p53 on HBV transcription, and consequently it acts as a tumor-suppressor through both a decrease in HBV replication and by directly targeting CYCLIN G1, as well as Wnt/beta-catenin, and NDRG3 pathways. This paper will briefly discuss the underlying mechanisms for the dual role of miR-122 in viral hepatitis, and explains why therapeutic applications of miR-122 may differ based on the underlying disease.

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APA: Copy

SENDI, HOSSEIN. (2012). DUAL ROLE OF MIR-122 IN MOLECULAR PATHOGENESIS OF VIRAL HEPATITIS. HEPATITIS MONTHLY, 12(5), 312-314. SID. https://sid.ir/paper/306527/en

Vancouver: Copy

SENDI HOSSEIN. DUAL ROLE OF MIR-122 IN MOLECULAR PATHOGENESIS OF VIRAL HEPATITIS. HEPATITIS MONTHLY[Internet]. 2012;12(5):312-314. Available from: https://sid.ir/paper/306527/en

IEEE: Copy

HOSSEIN SENDI, “DUAL ROLE OF MIR-122 IN MOLECULAR PATHOGENESIS OF VIRAL HEPATITIS,” HEPATITIS MONTHLY, vol. 12, no. 5, pp. 312–314, 2012, [Online]. Available: https://sid.ir/paper/306527/en

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