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Information Journal Paper

Title

A RANDOMIZED CONTROLLED TRIAL OF TWO SCHEDULES OF HEPATITIS B VACCINATION IN PREDIALYSED CHRONIC RENAL FAILURE PATIENTS

Pages

  344-348

Abstract

 Background: Patients with CHRONIC renal disease should be vaccinated as soon as dialysis is forestalled, and this could improve the seroconversion of HEPATITIS B VACCINATION. Objectives: In this study, we aimed to compare seroconversion and immune response rates using 4 doses of 40 mg and 3 doses of 20 mg Euvax B recombinant HEPATITIS B surface Antigen (HBs Ag) vaccine administered to predialysis patients with CHRONIC kidney disease (CKD). Patients and Methods: In an open, randomized clinical trial, we compared seroconversion rates in 51 predialysis patients with mild and moderate CHRONIC renal failure who received either 4 doses of 40 mg or 3 doses of 20 mg of Euvax B recombinant HEPATITIS B vaccine administered at 0, 1, 2, 6 and 0, 1, 6 months, respectively.Results: Differences in seroconversion rates after 4 doses of 40 mg (80.88%) compared to 3 doses of 20 mg (92%) were not significant (P = 0.4124). The mean HBs antibody level after 4 doses of 40 mg at 0, 1, 2, and 6 months (182.2 ± 286.7) was significantly higher than that after 3 doses of 40 mg at 0,1, and 6 months (96.9 ± 192.1) (P = 0.004). Seroconversion after 4 doses of 40 mg (80.8%) was also significantly higher than that after 3 doses of 40 mg (77%) (P = 0.004). Multivariable analysis showed that none of the variables contributed to seroconversion.Conclusions: We found that 4 doses of 40 mg did not lead to significantly more seroconversion than 3 doses of 20 mg.

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    APA: Copy

    AHMADI, FAROKHLAGHA, RAMEZANI, MORTEZA, RAZEGHI, EFFAT, RANJBARNOVIN, NEDA, & KHAZAEIPOUR, ZAHRA. (2012). A RANDOMIZED CONTROLLED TRIAL OF TWO SCHEDULES OF HEPATITIS B VACCINATION IN PREDIALYSED CHRONIC RENAL FAILURE PATIENTS. HEPATITIS MONTHLY, 12(5), 344-348. SID. https://sid.ir/paper/306528/en

    Vancouver: Copy

    AHMADI FAROKHLAGHA, RAMEZANI MORTEZA, RAZEGHI EFFAT, RANJBARNOVIN NEDA, KHAZAEIPOUR ZAHRA. A RANDOMIZED CONTROLLED TRIAL OF TWO SCHEDULES OF HEPATITIS B VACCINATION IN PREDIALYSED CHRONIC RENAL FAILURE PATIENTS. HEPATITIS MONTHLY[Internet]. 2012;12(5):344-348. Available from: https://sid.ir/paper/306528/en

    IEEE: Copy

    FAROKHLAGHA AHMADI, MORTEZA RAMEZANI, EFFAT RAZEGHI, NEDA RANJBARNOVIN, and ZAHRA KHAZAEIPOUR, “A RANDOMIZED CONTROLLED TRIAL OF TWO SCHEDULES OF HEPATITIS B VACCINATION IN PREDIALYSED CHRONIC RENAL FAILURE PATIENTS,” HEPATITIS MONTHLY, vol. 12, no. 5, pp. 344–348, 2012, [Online]. Available: https://sid.ir/paper/306528/en

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