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Information Journal Paper

Title

ERA OF VACCINATION HERALDS A DECLINE IN INCIDENCE OF HEPATITIS A IN HIGH- RISK GROUPS IN CHINA

Pages

  100-105

Abstract

 Background: HEPATITIS A was ranked first among all of the different types of viral hepatitis in CHINA, which occurred an average of 500, 000 cases annually during the 1980’s. A live attenuated HEPATITIS A vaccine was applied in preventing of the disease in 1992, large scale used in VACCINATION program in 1995, and incorporated in the Expanded Program of Immunization in 2008 in CHINA.Objective: The objective of this study was to determine whether, and to what extent, the decline in the incidence of HEPATITIS A in CHINA was the result of HEPATITIS A (HA) VACCINATION.Materials and Methods: Official documents and longitudinal serological follow-up studies were reviewed to compare the incidence of HA before and after the introduction of the vaccine.Results: National trends in the incidence of HA in CHINA saw rates decrease by 92.7% in 2009, compared to the levels seen in 1992. A mass VACCINATION program was carried out in 3-18 year old children (Wuhan City, CHINA), and its protective efficacy was 85.4%. In a mass VACCINATION program of an entire population (Shenshi County, CHINA), the annual HA incidence decreased from 359.7/100, 000 to 17.7/100, 000 (almost 20.3 times). There was a significant relationship found between vaccine coverage and the incidence of HA, the correlation of the negative regression was significant at the 1% (Kendall rank correlation, significant level P<0.05).Conclusions: In summary, this study highlights the important role of implementing a VACCINATION program in decreasing the incidence of HA, and the large protective efficacy of such a strategy, as demonstrated in CHINA.

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    APA: Copy

    FANGCHENG, ZHUANG, XUANYI, WANG, MINGDING, CHEN, LIMING, JIANG, JIE, WU, QI, JIANG, YUANPING, GONG, WEN, QIAN, YAJUAN, XIN, & JIANGSEN, MAO. (2012). ERA OF VACCINATION HERALDS A DECLINE IN INCIDENCE OF HEPATITIS A IN HIGH- RISK GROUPS IN CHINA. HEPATITIS MONTHLY, 12(2), 100-105. SID. https://sid.ir/paper/306564/en

    Vancouver: Copy

    FANGCHENG ZHUANG, XUANYI WANG, MINGDING CHEN, LIMING JIANG, JIE WU, QI JIANG, YUANPING GONG, WEN QIAN, YAJUAN XIN, JIANGSEN MAO. ERA OF VACCINATION HERALDS A DECLINE IN INCIDENCE OF HEPATITIS A IN HIGH- RISK GROUPS IN CHINA. HEPATITIS MONTHLY[Internet]. 2012;12(2):100-105. Available from: https://sid.ir/paper/306564/en

    IEEE: Copy

    ZHUANG FANGCHENG, WANG XUANYI, CHEN MINGDING, JIANG LIMING, WU JIE, JIANG QI, GONG YUANPING, QIAN WEN, XIN YAJUAN, and MAO JIANGSEN, “ERA OF VACCINATION HERALDS A DECLINE IN INCIDENCE OF HEPATITIS A IN HIGH- RISK GROUPS IN CHINA,” HEPATITIS MONTHLY, vol. 12, no. 2, pp. 100–105, 2012, [Online]. Available: https://sid.ir/paper/306564/en

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