GB VIRUS C INFECTION IN PATIENTS WITH HIV/HEPATITIS C VIRUS COINFECTION: IMPROVEMENT OF THE LIVER FUNCTION IN CHRONIC HEPATITIS C

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FENG YUE; LIU LI; FENG YUE MEI; ZHAO WENHUA; LI ZHENG; ZHANG A MEI; SONG YUZHU; XIA XUESHAN

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Journal: Hepatitis Monthly Year:2014 | Volume:14 | Issue:3 Page(s): 1-5

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Title

GB VIRUS C INFECTION IN PATIENTS WITH HIV/HEPATITIS C VIRUS COINFECTION: IMPROVEMENT OF THE LIVER FUNCTION IN CHRONIC HEPATITIS C

Author(s)

Keywords

GB VIRUS C

COINFECTION

HIV

HEPATITIS C VIRUS

LIVER FUNCTION TESTS

Abstract

Background: Previous studies in patients with HEPATITIS C VIRUS (HCV) /HIV COINFECTION have shown that the presence of GBV-C is associated with significantly less compensated and decompensated cirrhosis, and an improvement in cirrhosis-free survival.Objectives: This study aimed to describe the effect of GBV-C in patients with chronic hepatitis C and HIV COINFECTION.Patients and Methods: We retrospectively studied 105 injecting drug users with chronic hepatitis C and HIV COINFECTION and 72 patients with chronic HCV mono-infections. Plasma samples were tested for GBV-C RNA with primers to the 5’ untranslated region gene. HIV and HCV viral load, CD4+and CD8+cell count, and the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were tested in all patients.Results: GBV-C RNA was identified in 34 (32.38%) of the patients with HIV/HCV COINFECTION, and in 24 (33.33%) of the patients with HCV mono-infection. GBV-C infection was associated with significantly lower ALT and AST levels in patients with chronic hepatitis C and HIV COINFECTION, but not in those HCV mono-infections. The presence of GBV-C infection was not correlated with CD4+and CD8+cell count, gender, age, HIV load, HCV load, and HCV genotype.Conclusions: This study found that GBV-C infection has a high frequency among injecting drug users with HIV/HCV COINFECTION and HCV mono-infection in Yunnan, China. In patients with chronic hepatitis C and HIV COINFECTION, GBV-C RNA was associated with significantly lower ALT and AST levels, suggesting a beneficial effect of GBV-C infection on chronic hepatitis C.

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