PERSISTENT HEPATITIS E VIRUS GENOTYPE 4 INFECTION IN A CHILD WITH ACUTE LYMPHOBLASTIC LEUKEMIA

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GENG YANSHENG; ZHANG HONGXIN; HUANG WEIJIN; HARRISON TIM J.; GENG KUNJING; LI ZHUO; WANG YOUCHUN

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Journal: Hepatitis Monthly Year:2014 | Volume:14 | Issue:1 Page(s): 1-4

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Title

PERSISTENT HEPATITIS E VIRUS GENOTYPE 4 INFECTION IN A CHILD WITH ACUTE LYMPHOBLASTIC LEUKEMIA

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Keywords

HEPATITIS E VIRUS

PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA

CHRONIC HEPATITIS

PERSISTENT INFECTION

Abstract

Introduction: In general, the HEPATITIS E VIRUS (HEV) causes acute, self-limiting hepatitis. Prolonged and chronic infections caused by HEV genotype 3 have been found in some immunosuppressed patients in developed countries.Case Presentation: Here we report a Chinese boy with acute lymphoblastic leukemia, who developed hepatitis E during a period of intensive chemotherapy. Twenty months after the initial infection, HEV viremia was reappeared in the patient, with detectable anti-HEV IgM and IgG and modestly elevated serum transaminases. Sequence analysis of the viral RNAs revealed the reactivation of the HEV genotype 4d strain, indicating viral persistence in the patient.Conclusions: To our knowledge, this is the first chronic case confirmed by the prolonged presence of HEV RNA in china. It is also the first reported persistent hepatitis E infection caused by HEV genotype 4.

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APA: Copy

GENG, YANSHENG, ZHANG, HONGXIN, HUANG, WEIJIN, HARRISON, TIM J., GENG, KUNJING, LI, ZHUO, & WANG, YOUCHUN. (2014). PERSISTENT HEPATITIS E VIRUS GENOTYPE 4 INFECTION IN A CHILD WITH ACUTE LYMPHOBLASTIC LEUKEMIA. HEPATITIS MONTHLY, 14(1), 1-4. SID. https://sid.ir/paper/306587/en

Vancouver: Copy

GENG YANSHENG, ZHANG HONGXIN, HUANG WEIJIN, HARRISON TIM J., GENG KUNJING, LI ZHUO, WANG YOUCHUN. PERSISTENT HEPATITIS E VIRUS GENOTYPE 4 INFECTION IN A CHILD WITH ACUTE LYMPHOBLASTIC LEUKEMIA. HEPATITIS MONTHLY[Internet]. 2014;14(1):1-4. Available from: https://sid.ir/paper/306587/en

IEEE: Copy

YANSHENG GENG, HONGXIN ZHANG, WEIJIN HUANG, TIM J. HARRISON, KUNJING GENG, ZHUO LI, and YOUCHUN WANG, “PERSISTENT HEPATITIS E VIRUS GENOTYPE 4 INFECTION IN A CHILD WITH ACUTE LYMPHOBLASTIC LEUKEMIA,” HEPATITIS MONTHLY, vol. 14, no. 1, pp. 1–4, 2014, [Online]. Available: https://sid.ir/paper/306587/en

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