DECREASE OF SERUM ANGIOTENSIN CONVERTING ENZYME LEVELS UPON TELBIVUDINE TREATMENT FOR CHRONIC HEPATITIS B VIRUS INFECTION AND NEGATIVE CORRELATIONS BETWEEN THE ENZYME LEVELS AND ESTIMATED GLUMERULAR FILTRATION RATES

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LIANG KUNG HAO; CHEN YI CHENG; HSU CHAO WEI; CHANG MING LING; YEH CHAU TING

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Hepatitis Monthly Year:2014 | Volume:14 | Issue:1 Page(s): 1-7

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Title

DECREASE OF SERUM ANGIOTENSIN CONVERTING ENZYME LEVELS UPON TELBIVUDINE TREATMENT FOR CHRONIC HEPATITIS B VIRUS INFECTION AND NEGATIVE CORRELATIONS BETWEEN THE ENZYME LEVELS AND ESTIMATED GLUMERULAR FILTRATION RATES

Author(s)

Keywords

HEPATITIS B

NUCLEOSIDES

ANTIVIRAL AGENTS

KIDNEY

Abstract

Background: During antiviral therapy for chronic HEPATITIS B, renal function impairment could be a critical concern when oral nucleot (s) ide analogues were used. Paradoxically, long-term telbivudine treatment was associated with an increase of estimated glomerular filtration rate (eGFR) through unknown mechanisms.Objectives: We aimed to investigate changes in serum protein abundances associated with renal function in response to antiviral treatments.Materials and Methods: Primarily, a transcriptomic assay was performed to identify differentially expressed genes in peripheral blood cells caused by the telbivudine treatment. Two genes coding angiotensin converting enzyme (ACE) and complement factor H (CFH) were screened from 14 candidate renal function-related genes. ACE and CFH production were further investigated using enzyme-linked immunoassays.Results: Verification studies showed no significant change of serum CFH levels, but there was a significant reduction of serum ACE levels by continuous telbivudine treatment for 330.00±0.85 days (34 patients, paired t-test, P=0.022). Serum HBV DNA and ALT levels also decreased (P=0.008 and<0.001, respectively). A significant increase in eGFR was found (33 patients, paired t-test, P=0.002) at 708.64±31.63 days. Patients’ eGFRs were negatively correlated with serum ACE levels (r=-0.375, P=0.002) but not with serum HBV DNA and ALT levels (P=0.241 and 0.088 respectively). Significant decreases of the ACE levels were also observed upon entecavir treatment (20 patients, paired t-test, P=0.020) at 412.88±36.92 days. No significant correlation was found between serum ACE levels and eGFRs (r=-0.239, P=0.138) in entecavir-treated patients.Conclusions: We discovered a consistent reduction of serum ACE levels by two oral antiviral monotherapies, entecavir and telbivudine. Serum ACE levels were negatively correlated with eGFRs in telbivudine treated patients.

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APA: Copy

LIANG, KUNG HAO, CHEN, YI CHENG, HSU, CHAO WEI, CHANG, MING LING, & YEH, CHAU TING. (2014). DECREASE OF SERUM ANGIOTENSIN CONVERTING ENZYME LEVELS UPON TELBIVUDINE TREATMENT FOR CHRONIC HEPATITIS B VIRUS INFECTION AND NEGATIVE CORRELATIONS BETWEEN THE ENZYME LEVELS AND ESTIMATED GLUMERULAR FILTRATION RATES. HEPATITIS MONTHLY, 14(1), 1-7. SID. https://sid.ir/paper/306599/en

Vancouver: Copy

LIANG KUNG HAO, CHEN YI CHENG, HSU CHAO WEI, CHANG MING LING, YEH CHAU TING. DECREASE OF SERUM ANGIOTENSIN CONVERTING ENZYME LEVELS UPON TELBIVUDINE TREATMENT FOR CHRONIC HEPATITIS B VIRUS INFECTION AND NEGATIVE CORRELATIONS BETWEEN THE ENZYME LEVELS AND ESTIMATED GLUMERULAR FILTRATION RATES. HEPATITIS MONTHLY[Internet]. 2014;14(1):1-7. Available from: https://sid.ir/paper/306599/en

IEEE: Copy

KUNG HAO LIANG, YI CHENG CHEN, CHAO WEI HSU, MING LING CHANG, and CHAU TING YEH, “DECREASE OF SERUM ANGIOTENSIN CONVERTING ENZYME LEVELS UPON TELBIVUDINE TREATMENT FOR CHRONIC HEPATITIS B VIRUS INFECTION AND NEGATIVE CORRELATIONS BETWEEN THE ENZYME LEVELS AND ESTIMATED GLUMERULAR FILTRATION RATES,” HEPATITIS MONTHLY, vol. 14, no. 1, pp. 1–7, 2014, [Online]. Available: https://sid.ir/paper/306599/en

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