HEPATITIS B VIRUS CORE PROMOTER MUTATIONS IN PATIENTS WITH CHRONIC HEPATITIS B AND HEPATOCELLULAR CARCINOMA IN BUCHAREST, ROMANIA

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CONSTANTINESCU ILEANA; ANDREI ANTONIU DINU; BOSCAIU VOICU; NICULESCU MARIUS

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Journal: Hepatitis Monthly Year:2014 | Volume:14 | Issue:10 Page(s): 0-0

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Title

HEPATITIS B VIRUS CORE PROMOTER MUTATIONS IN PATIENTS WITH CHRONIC HEPATITIS B AND HEPATOCELLULAR CARCINOMA IN BUCHAREST, ROMANIA

Author(s)

CONSTANTINESCU ILEANA | ANDREI ANTONIU DINU | BOSCAIU VOICU | NICULESCU MARIUS | Issue Writer Certificate

Keywords

HEPATITIS B VIRUS

HEPATOCELLULAR CARCINOMA

GENOTYPE

MUTATIONS

Abstract

Background: Accurate and personalized molecular virological diagnosis of HEPATITIS B VIRUS (HBV) infection is crucial for individualized selection of patients for antiviral therapy in Romania.Objectives: We aimed to investigate HBV MUTATIONS in Romanian patients with chronic HBV infection, also to match HBV GENOTYPEs with HBV MUTATIONS identified and clinical outcomes.Patients and Methods: This was a cross-sectional study. A total of 484 Romanian patients with chronic HBV infection and HEPATOCELLULAR CARCINOMA (HCC) were investigated. This was performed in Fundeni Clinical Institute, Bucharest, Romania during January 2005 to August 2010. HBsAg positive patients with chronic HBV infection admitted to Fundeni Clinical Institute were randomly enrolled in the study. Analysis was performed in the Centre for Immunogenetics and Virology, Fundeni Clinical Institute, Bucharest, Romania. Indirect diagnosis was performed with enhanced chemiluminescence method using Architect i2000SR and HBV-DNA was quantified with COBAS TaqMan HBV PCR. Direct sequencing of the PCR-products was performed with the PCR-product sequencing kit. HBV genotyping was performed with INNO-LiPA DR Amplification and INNO-LiPA HBV precore-core.Results: We detected two HBV GENOTYPEs, A (8.1%) and D (60.5%), and a mixture of GENOTYPEs A and D (31.4%) (P<0.001). Basal core promoter (BCP) A1762T/G1764A and precore (PC) G1896A MUTATIONS were detected in these Romanian patients with chronic HBV infection. HBV chronic carriers had mainly GENOTYPE D (54.4%) and HBV WT (64.0%). BCP A1762T, G1764A and PC G1896A were significantly associated with HCC-tissue HBV sequencing (75.3%) (P<0.001). PC G1896A alone was detected in HCC-serum HBV sequencing group (66.7%).Conclusions: GENOTYPE D was the main GENOTYPE detected in Romanian patients with chronic HBV infection. GENOTYPE D presented both BCP and PC MUTATIONS more frequently.

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APA: Copy

CONSTANTINESCU, ILEANA, ANDREI ANTONIU, DINU, BOSCAIU, VOICU, & NICULESCU, MARIUS. (2014). HEPATITIS B VIRUS CORE PROMOTER MUTATIONS IN PATIENTS WITH CHRONIC HEPATITIS B AND HEPATOCELLULAR CARCINOMA IN BUCHAREST, ROMANIA. HEPATITIS MONTHLY, 14(10), 0-0. SID. https://sid.ir/paper/306602/en

Vancouver: Copy

CONSTANTINESCU ILEANA, ANDREI ANTONIU DINU, BOSCAIU VOICU, NICULESCU MARIUS. HEPATITIS B VIRUS CORE PROMOTER MUTATIONS IN PATIENTS WITH CHRONIC HEPATITIS B AND HEPATOCELLULAR CARCINOMA IN BUCHAREST, ROMANIA. HEPATITIS MONTHLY[Internet]. 2014;14(10):0-0. Available from: https://sid.ir/paper/306602/en

IEEE: Copy

ILEANA CONSTANTINESCU, DINU ANDREI ANTONIU, VOICU BOSCAIU, and MARIUS NICULESCU, “HEPATITIS B VIRUS CORE PROMOTER MUTATIONS IN PATIENTS WITH CHRONIC HEPATITIS B AND HEPATOCELLULAR CARCINOMA IN BUCHAREST, ROMANIA,” HEPATITIS MONTHLY, vol. 14, no. 10, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/306602/en

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