LACK OF ASSOCIATION BETWEEN TRANSFORMING GROWTH FACTOR BETA 1 -509C/T AND+915G/C POLYMORPHISMS AND CHRONIC HEPATITIS B IN IRANIAN PATIENTS

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HOSSEINI RAZAVI ARMIN; AZIMZADEH PEDRAM; MOHEBBI SEYED REZA; HOSSEINI SEYED MASOUD; ROMANI SARA; KHANYAGHMA MAHSA; HATAMI YASIN; SHARIFIAN AFSANEH; ZALI MOHAMMAD REZA

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Journal: Hepatitis Monthly Year:2014 | Volume:14 | Issue:4 Page(s): 0-0

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Title

LACK OF ASSOCIATION BETWEEN TRANSFORMING GROWTH FACTOR BETA 1 -509C/T AND+915G/C POLYMORPHISMS AND CHRONIC HEPATITIS B IN IRANIAN PATIENTS

Author(s)

Keywords

TRANSFORMING GROWTH FACTOR BETA 1

HEPATITIS B

CHRONIC

POLYMORPHISM

GENETIC

Abstract

Background: CHRONIC HEPATITIS B is one of the world's major health concern. The etiological agent of this infection is HEPATITIS B virus (HBV), which can evade the immune system response. TRANSFORMING GROWTH FACTOR BETA 1 (TGF- b1) can act against HBV by suppressing the viral replication. The TGF-b1 also plays an important role in preventing liver damage in CHRONICally HBV infected patients.Objectives: In this study, the association of TGF-b1+915G/C and -509C/T gene POLYMORPHISMs with CHRONIC HEPATITIS B was evaluated in Iranian patients.Materials and Methods: A population-based case–control study was conducted in Taleghani Hospital, Tehran. A number of 220 patients with CHRONIC HEPATITIS B and the same number of healthy control subjects were designated the case and the control groups. The PCR-Restriction Fragment Length POLYMORPHISM Method (PCR-RFLP) method was used for genotyping both POLYMORPHISMs. Ten percent of the control samples were sequenced to confirm the results.Results: No statically significant differences in genotype distribution and allele frequency were observed for both POLYMORPHISMs between healthy controls and patients with CHRONIC HEPATITIS B.Conclusions: There was no association between TGF- b1 -509C/T and+915G/C POLYMORPHISMs with CHRONIC HEPATITIS B and it seems that these changes don not play a significant role in increasing the risk of CHRONIC infection in Iranian patients.

Cites

A STUDY ON GENETIC ASSOCIATION OF INTERLEUKIN-16 SINGLE NUCLEOTIDE POLYMORPHISM (RS1131445) WITH CHRONIC HEPATITIS B VIRUS INFECTION IN IRANIAN PATIENTS

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APA: Copy

HOSSEINI RAZAVI, ARMIN, AZIMZADEH, PEDRAM, MOHEBBI, SEYED REZA, HOSSEINI, SEYED MASOUD, ROMANI, SARA, KHANYAGHMA, MAHSA, HATAMI, YASIN, SHARIFIAN, AFSANEH, & ZALI, MOHAMMAD REZA. (2014). LACK OF ASSOCIATION BETWEEN TRANSFORMING GROWTH FACTOR BETA 1 -509C/T AND+915G/C POLYMORPHISMS AND CHRONIC HEPATITIS B IN IRANIAN PATIENTS. HEPATITIS MONTHLY, 14(4), 0-0. SID. https://sid.ir/paper/306656/en

Vancouver: Copy

HOSSEINI RAZAVI ARMIN, AZIMZADEH PEDRAM, MOHEBBI SEYED REZA, HOSSEINI SEYED MASOUD, ROMANI SARA, KHANYAGHMA MAHSA, HATAMI YASIN, SHARIFIAN AFSANEH, ZALI MOHAMMAD REZA. LACK OF ASSOCIATION BETWEEN TRANSFORMING GROWTH FACTOR BETA 1 -509C/T AND+915G/C POLYMORPHISMS AND CHRONIC HEPATITIS B IN IRANIAN PATIENTS. HEPATITIS MONTHLY[Internet]. 2014;14(4):0-0. Available from: https://sid.ir/paper/306656/en

IEEE: Copy

ARMIN HOSSEINI RAZAVI, PEDRAM AZIMZADEH, SEYED REZA MOHEBBI, SEYED MASOUD HOSSEINI, SARA ROMANI, MAHSA KHANYAGHMA, YASIN HATAMI, AFSANEH SHARIFIAN, and MOHAMMAD REZA ZALI, “LACK OF ASSOCIATION BETWEEN TRANSFORMING GROWTH FACTOR BETA 1 -509C/T AND+915G/C POLYMORPHISMS AND CHRONIC HEPATITIS B IN IRANIAN PATIENTS,” HEPATITIS MONTHLY, vol. 14, no. 4, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/306656/en

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