مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

A STUDY ON GENETIC ASSOCIATION OF INTERLEUKIN-16 SINGLE NUCLEOTIDE POLYMORPHISM (RS1131445) WITH CHRONIC HEPATITIS B VIRUS INFECTION IN IRANIAN PATIENTS

Pages

  1-5

Abstract

 Background: Interleukin-16 (IL-16) is an immunomodulatory cytokine, which plays an important role in some inflammatory and autoimmune diseases such as hepatitis B, which is a major health concern worldwide.Objectives: In this study, we aimed to investigate the plausible association between IL-16 POLYMORPHISM and chronic HBV susceptibility in an IRANian population.Patients and Methods: In a case-control study, we analyzed rs1131445 POLYMORPHISM in the microRNA binding site of the IL-16 gene in 262 patients with chronic hepatitis B and 269 healthy controls, using the POLYMERASE CHAIN REACTION-restriction fragment length POLYMORPHISM (PCR-RFLP) method and DNA sequencing technology to confirm our results.Results: Altogether, in this investigation, a significant association was observed between the IL-16 TC genotype compared with the TT genotype (OR=0.696, 95% CI: 0.485-0.997, P=0.048), after adjustments for confounders including age and gender.Conclusions: These findings show that immunogenetic factors, such as SINGLE NUCLEOTIDE POLYMORPHISM in IL-16, could be a risk factor for susceptibility to chronic HBV infection. However, further investigations are needed to verify these results.

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References

Cite

APA: Copy

BEHELGARDI, ABBAS, HOSSEINI, SEYED MASOUD, MOHEBBI, SEYED REZA, AZIMZADEH, PEDRAM, DERAKHSHANI, SHAGHAYEGH, KARIMI, KHATOON, SHARIFIAN, AFSANEH, & ZALI, MOHAMMAD REZA. (2015). A STUDY ON GENETIC ASSOCIATION OF INTERLEUKIN-16 SINGLE NUCLEOTIDE POLYMORPHISM (RS1131445) WITH CHRONIC HEPATITIS B VIRUS INFECTION IN IRANIAN PATIENTS. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 8(11), 1-5. SID. https://sid.ir/paper/317440/en

Vancouver: Copy

BEHELGARDI ABBAS, HOSSEINI SEYED MASOUD, MOHEBBI SEYED REZA, AZIMZADEH PEDRAM, DERAKHSHANI SHAGHAYEGH, KARIMI KHATOON, SHARIFIAN AFSANEH, ZALI MOHAMMAD REZA. A STUDY ON GENETIC ASSOCIATION OF INTERLEUKIN-16 SINGLE NUCLEOTIDE POLYMORPHISM (RS1131445) WITH CHRONIC HEPATITIS B VIRUS INFECTION IN IRANIAN PATIENTS. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2015;8(11):1-5. Available from: https://sid.ir/paper/317440/en

IEEE: Copy

ABBAS BEHELGARDI, SEYED MASOUD HOSSEINI, SEYED REZA MOHEBBI, PEDRAM AZIMZADEH, SHAGHAYEGH DERAKHSHANI, KHATOON KARIMI, AFSANEH SHARIFIAN, and MOHAMMAD REZA ZALI, “A STUDY ON GENETIC ASSOCIATION OF INTERLEUKIN-16 SINGLE NUCLEOTIDE POLYMORPHISM (RS1131445) WITH CHRONIC HEPATITIS B VIRUS INFECTION IN IRANIAN PATIENTS,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 8, no. 11, pp. 1–5, 2015, [Online]. Available: https://sid.ir/paper/317440/en

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