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Title

HEPATITIS B SPLICE-GENERATED PROTEIN ANTIBODIES IN SYRIAN CHRONIC HEPATITIS B PATIENTS: INCIDENCE AND SIGNIFICANCE

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Abstract

 Background: Previous studies have suggested HEPATITIS B splice-generated protein (HBSP), when expressed, is involved in the pathogenesis of HBV infection.Objectives: We aimed to evaluate anti-HBSP incidence and association with several HBV infection parameters in a group of SYRIAn CHRONIC HEPATITIS B patients.Patients and Methods: Eighty treatment-naïve HBsAg-positive adult CHRONIC HEPATITIS B patients' sera were included in our prospective targeted study. Liver function, virological and histological tests results were obtained from patients’ medical files. Three variants of a 20-mer HBSP-derived peptide were designed based on HBV genome sequences obtained from SYRIAn patients' sera (GenBank Accession No. JN257148-JN257217). Microtiter plate wells were coated with the synthetic peptides and used to detect anti-HBSP antibodies by an optimized indirect enzyme-linked immunosorbent assay (ELISA). Samples were considered positive when showed optical density (OD) values higher than the cut-off value for at least one peptide variant.Results: Seven out of eighty (9%) CHB patients were positive for anti-HBSP antibodies. Mean OD values were not significantly different between HBeAg-positive and -negative patients (P>0.05). OD values showed weak positive correlation with ALT and AST values (P<0.05), and weak to moderate positive correlation with liver biopsy staging ranks (P<0.05). No significant correlation was revealed with viral load values or liver biopsy grading ranks (P>0.05).Conclusions: We introduced an anti-HBSP antibodies ELISA, designed for locally circulating HBV strains. Correlation observed of Anti-HBSP with liver fibrosis staging regardless of viral replication and liver inflammation suggests anti-HBSP antibodies as possible indicator for HBV-associated liver fibrosis.

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    APA: Copy

    AL HANAFI, NOUR, & MONEM, FAWZA. (2014). HEPATITIS B SPLICE-GENERATED PROTEIN ANTIBODIES IN SYRIAN CHRONIC HEPATITIS B PATIENTS: INCIDENCE AND SIGNIFICANCE. HEPATITIS MONTHLY, 14(4), 0-0. SID. https://sid.ir/paper/306664/en

    Vancouver: Copy

    AL HANAFI NOUR, MONEM FAWZA. HEPATITIS B SPLICE-GENERATED PROTEIN ANTIBODIES IN SYRIAN CHRONIC HEPATITIS B PATIENTS: INCIDENCE AND SIGNIFICANCE. HEPATITIS MONTHLY[Internet]. 2014;14(4):0-0. Available from: https://sid.ir/paper/306664/en

    IEEE: Copy

    NOUR AL HANAFI, and FAWZA MONEM, “HEPATITIS B SPLICE-GENERATED PROTEIN ANTIBODIES IN SYRIAN CHRONIC HEPATITIS B PATIENTS: INCIDENCE AND SIGNIFICANCE,” HEPATITIS MONTHLY, vol. 14, no. 4, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/306664/en

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