PREVALENCE OF HEPATITIS DELTA VIRUS (HDV) INFECTION IN CHRONIC HEPATITIS B PATIENTS WITH UNUSUAL CLINICAL PICTURES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GHAMARI SHIVA; ALAVIAN SEYED MOAYED; RIZZETTO MARIO; OLIVERO ANTONELLA; SMEDILE ANTONINA; KHEDIVE ABULFAZL; ALAVIAN SEYED EHSAN; ZOLFAGHARI MOHAMMAD REZA; JAZAYERI SEYED MOHAMMAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Hepatitis Monthly Year:2013 | Volume:13 | Issue:8 Page(s): 1-8

Download Full-Text

View:

348

Download:

155

Cites:

Information Journal Paper

Title

PREVALENCE OF HEPATITIS DELTA VIRUS (HDV) INFECTION IN CHRONIC HEPATITIS B PATIENTS WITH UNUSUAL CLINICAL PICTURES

Author(s)

Keywords

HEPATITIS DELTA VIRUS

PREVALENCE

ANTIBODIES

Abstract

Background: Probably 5% of the HBV carriers have HDV super infection. The risk of fulminant hepatitis, cirrhosis and hepatocellular carcinoma is higher in superinfection than the settings when HBV is alone.Objectives: The aim of this study was to evaluate the PREVALENCE of HDV in Iranian HBV isolates and to compare their clinical and virological pictures as well as their HDV genetic variations with other worldwide isolates.Patients and Methods: 81 carriers with positive results for HBsAg with upper limit ranges of ALT and low or undetectable levels of HBV viral load who did not respond to HBV therapy were selected. After RT amplification of HDV Delta antigen, direct sequencing and phylogenetic study were performed to explore the genotype(s) and nucleotide/amino acid variations.Results: 12 (14.8%) patients had positive results for both HDV RNA and anti-HDV. The mean ALT level was higher in HDV positive patients (75.9 U/ML) than HBV-mono-infected individuals; however, the mean HBV viral load was lower in coinfected patients than HBV-mono-infected patients. Phylogenetically, genotype I was the only detected genotype, and the most closely related isolates were of Turkish, Italian and Mongolian origin. Within the delta Ag, there were 326 nucleotide mutations, of which 111 and 215 were silent and missense, respectively. The total number of amino acid substitution was 148; most were located in known functional/epitopic domains. There was no correlation between the numbers of amino acid mutations, with clinical, virological status of the patients.Conclusions: HDV should be suspected in HBV carriers with unusual clinical and virological pictures. Relatedness of Iranian HDV isolates to Italian and Turkish sequences proposed a common Caucasian origin for the distribution of HDV genotype I in this ethnic group.

Cites

No record.

References

No record.

Cite

APA: Copy

GHAMARI, SHIVA, ALAVIAN, SEYED MOAYED, RIZZETTO, MARIO, ZOLFAGHARI, MOHAMMAD REZA, & JAZAYERI, SEYED MOHAMMAD. (2013). PREVALENCE OF HEPATITIS DELTA VIRUS (HDV) INFECTION IN CHRONIC HEPATITIS B PATIENTS WITH UNUSUAL CLINICAL PICTURES. HEPATITIS MONTHLY, 13(8), 1-8. SID. https://sid.ir/paper/306693/en

Vancouver: Copy

GHAMARI SHIVA, ALAVIAN SEYED MOAYED, RIZZETTO MARIO, ZOLFAGHARI MOHAMMAD REZA, JAZAYERI SEYED MOHAMMAD. PREVALENCE OF HEPATITIS DELTA VIRUS (HDV) INFECTION IN CHRONIC HEPATITIS B PATIENTS WITH UNUSUAL CLINICAL PICTURES. HEPATITIS MONTHLY[Internet]. 2013;13(8):1-8. Available from: https://sid.ir/paper/306693/en

IEEE: Copy

SHIVA GHAMARI, SEYED MOAYED ALAVIAN, MARIO RIZZETTO, MOHAMMAD REZA ZOLFAGHARI, and SEYED MOHAMMAD JAZAYERI, “PREVALENCE OF HEPATITIS DELTA VIRUS (HDV) INFECTION IN CHRONIC HEPATITIS B PATIENTS WITH UNUSUAL CLINICAL PICTURES,” HEPATITIS MONTHLY, vol. 13, no. 8, pp. 1–8, 2013, [Online]. Available: https://sid.ir/paper/306693/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops