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Title

ASSOCIATION BETWEEN ABCB1 (MDR1) GENE POLYMORPHISM AND UNRESPONSIVENESS COMBINED THERAPY IN CHRONIC HEPATITIS C VIRUS

Pages

  1-6

Abstract

 Background: To treat viral infection of chronic HEPATITIS C (CHC) is a main strategy to prevent progression of liver disease, and cancer. Some patients with CHC have failed to respond to the common antiviral therapy in different populations.Objectives: In the current study it was aimed to find out the possible role of multiple drug resistance gene1 (MDR1) in non-responder patients with CHC infection in Turkish population.Patients and Methods: Peripheral blood-EDTA samples were used for total genomic DNA isolation. In total of 55 patients with chronic HEPATITIS C and positive results for genotype 1 [31 male (56.4%), 24 female (43.6%) and mean age-min-max; 56.9±9.66 (39-71)]; 19 responder (34.5%), 21 non responder (38.2%), and 15 recurrence (27.3%) were included in the presented results. Functional MDR1 gene was genotyped by multiplex PCR-based reverse-hybridization Strip Assay method, and some samples were confirmed by direct sequencing.Results: Our results indicate that MDR1 gene polymorphism is strongly associated with non-responder patients and those with recurrent chronic HEPATITIS C during conventional drug therapy when compared to the responder patients. Homozygous of the TT genotype for MDR1 exon 26 polymorphism was at 2.0-fold higher risk of non-responder than patients with CC and CT.Conclusions: The homozygous MDR1 3435TT genotype which encodes the xenobiotic transporter P-glycoprotein may be associated with a poor antiviral response in HCV chronicity during conventional therapy, and large-scale studies are needed to validate this association.

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    APA: Copy

    TIMUCIN, MERYEM, ALAGOZLU, HAKAN, OZDEMIR, SEMRA, & OZDEMIR, OZTURK. (2013). ASSOCIATION BETWEEN ABCB1 (MDR1) GENE POLYMORPHISM AND UNRESPONSIVENESS COMBINED THERAPY IN CHRONIC HEPATITIS C VIRUS. HEPATITIS MONTHLY, 13(4), 1-6. SID. https://sid.ir/paper/306748/en

    Vancouver: Copy

    TIMUCIN MERYEM, ALAGOZLU HAKAN, OZDEMIR SEMRA, OZDEMIR OZTURK. ASSOCIATION BETWEEN ABCB1 (MDR1) GENE POLYMORPHISM AND UNRESPONSIVENESS COMBINED THERAPY IN CHRONIC HEPATITIS C VIRUS. HEPATITIS MONTHLY[Internet]. 2013;13(4):1-6. Available from: https://sid.ir/paper/306748/en

    IEEE: Copy

    MERYEM TIMUCIN, HAKAN ALAGOZLU, SEMRA OZDEMIR, and OZTURK OZDEMIR, “ASSOCIATION BETWEEN ABCB1 (MDR1) GENE POLYMORPHISM AND UNRESPONSIVENESS COMBINED THERAPY IN CHRONIC HEPATITIS C VIRUS,” HEPATITIS MONTHLY, vol. 13, no. 4, pp. 1–6, 2013, [Online]. Available: https://sid.ir/paper/306748/en

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