A SURVEY OF CORRELATION BETWEEN INSULIN-LIKE GROWTH FACTOR-I (IGF-I) LEVELS AND SEVERITY OF LIVER CIRRHOSIS

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KHOSHNOOD ASGHAR; NASIRI TOOSI MOHSEN; FARAVASH MOHAMMAD JAFAR; ESTEGHAMATI ALIREZA; FROUTAN HOSSEIN; GHOFRANI HADI; KALANI MOHAMMAD; MIROLIAEE ARASH; ABDOLLAHI AHMAD; ANDRABI YASIR

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Journal: Hepatitis Monthly Year:2013 | Volume:13 | Issue:2 Page(s): 0-0

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Title

A SURVEY OF CORRELATION BETWEEN INSULIN-LIKE GROWTH FACTOR-I (IGF-I) LEVELS AND SEVERITY OF LIVER CIRRHOSIS

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INSULIN-LIKE GROWTH FACTOR I

LIVER CIRRHOSIS

CHILD

Abstract

Background: INSULIN-LIKE GROWTH FACTOR Is a polypeptide with endocrine, autocrine and paracrine effects which its structure is similar to the insulin molecule. While various tissues secrete IGF-1, 90% of the circulating IGF-1 is secreted by liver. Cirrhosis of liver is a condition accompanied by decreased level of IGF-1, in which the level of IGF-1 may be further decreased thorough the progression of the disease. Objectives: The aim of the present study was to demonstrate the relation between the IGF-1 levels and severity of liver disease according to CHILD- Pugh and Model for end stage liver diseases (MELD) Scores. Patients and Method: This was a descriptive-analytic cross sectional study performed on patients with cirrhosis admitted to gastroenterology clinic of Imam Khomeini Hospital in Tehran, Iran during the years 2007-2008. The diagnosis was based on liver biopsy. Initially for all patients, laboratory investigations including IGF-1, CBC, liver Enzymes, Alkaline phosphates, serum Albumin, Creatinine, direct and total Bilirubin were conducted. Also ultrasound and endoscopy were performed for evaluation of ascites and varices.Results: 100 patients with cirrhosis with a male to Female ratio of 63: 37 and a mean age of 44.4 ± 15 years were enrolled in the study. Median IGF-1 was 92.95 ± 91.51 ng/mL.14 patients (14%) had IGF-1 within normal limits while 86 patients (86%) had abnormal IGF-1 levels. In all patients the correlation coefficient between IGF-1 and MELD was -0.317 (P=0.001) and 0.478 between IGF-1 and CHILD- Pugh (P<0.001). Conclusions: Our findings showed that IGF-1 can be used as an index for evaluating the severity of cirrhosis; also it can be used for determining the severity of the disease, when liver biopsy is not possible.

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APA: Copy

KHOSHNOOD, ASGHAR, NASIRI TOOSI, MOHSEN, FARAVASH, MOHAMMAD JAFAR, ESTEGHAMATI, ALIREZA, FROUTAN, HOSSEIN, GHOFRANI, HADI, KALANI, MOHAMMAD, MIROLIAEE, ARASH, ABDOLLAHI, AHMAD, & ANDRABI, YASIR. (2013). A SURVEY OF CORRELATION BETWEEN INSULIN-LIKE GROWTH FACTOR-I (IGF-I) LEVELS AND SEVERITY OF LIVER CIRRHOSIS. HEPATITIS MONTHLY, 13(2), 0-0. SID. https://sid.ir/paper/306752/en

Vancouver: Copy

KHOSHNOOD ASGHAR, NASIRI TOOSI MOHSEN, FARAVASH MOHAMMAD JAFAR, ESTEGHAMATI ALIREZA, FROUTAN HOSSEIN, GHOFRANI HADI, KALANI MOHAMMAD, MIROLIAEE ARASH, ABDOLLAHI AHMAD, ANDRABI YASIR. A SURVEY OF CORRELATION BETWEEN INSULIN-LIKE GROWTH FACTOR-I (IGF-I) LEVELS AND SEVERITY OF LIVER CIRRHOSIS. HEPATITIS MONTHLY[Internet]. 2013;13(2):0-0. Available from: https://sid.ir/paper/306752/en

IEEE: Copy

ASGHAR KHOSHNOOD, MOHSEN NASIRI TOOSI, MOHAMMAD JAFAR FARAVASH, ALIREZA ESTEGHAMATI, HOSSEIN FROUTAN, HADI GHOFRANI, MOHAMMAD KALANI, ARASH MIROLIAEE, AHMAD ABDOLLAHI, and YASIR ANDRABI, “A SURVEY OF CORRELATION BETWEEN INSULIN-LIKE GROWTH FACTOR-I (IGF-I) LEVELS AND SEVERITY OF LIVER CIRRHOSIS,” HEPATITIS MONTHLY, vol. 13, no. 2, pp. 0–0, 2013, [Online]. Available: https://sid.ir/paper/306752/en

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