PREDICTORS OF CHRONIC HEPATITIS C EVOLUTION IN HIV CO-INFECTED PATIENTS FROM ROMANIA

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SULTANA CAMELIA; ERSCOIU SIMONA MANUELA; GRANCEA CAMELIA; CEAUSU EMANOIL; RUTA SIMONA

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Journal: Hepatitis Monthly Year:2013 | Volume:13 | Issue:2 Page(s): 0-0

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Title

PREDICTORS OF CHRONIC HEPATITIS C EVOLUTION IN HIV CO-INFECTED PATIENTS FROM ROMANIA

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Keywords

COINFECTION

ROMANIA

BIOLOGICAL MARKERS

Abstract

Background: Due to a recent alarming increase in the number of HIV-HCV co-infected patients in ROMANIA. Objectives: A cross sectional study was conducted to assess the baseline predictors of liver disease evolution.Patients and Methods: 83 HIV-HCV co-infected patients, untreated for HCV infection, were evaluated for viral replication, liver fibrosis (estimated by a noninvasive marker - FIB4), and plasma levels of IP-10 (interferon-gamma inducible protein 10) - a cytokine associated with an unfavorable outcome of HCV infection.Results: The median value for HCV viral load was high (6.3 log10 IU/mL), 98.8% of the patients were infected with HCV genotype 1. Although 53% of the patients received antiretroviral therapy (cART), only 31.8% of these achieved undetectable HIV levels. HCV viral load was significantly higher in patients with AIDS (6.4 vs.6.1 log10IU/mL; P=0.04), and in those naïve for cART (6.5 vs.5.9 log10 IU/mL; P=0.04). Severe fibrosis was directly correlated with immunosupression (56% vs.17.4%, P=0.03), HCV replication (6.1 vs.4.9 log10IU/mL P=0.008), and IP-10 median values (312 vs.139 pg/ml, P=0.008). A serum IP-10 level higher than 400 pg/mL was significantly associated with FIB-4 median values (4.09 vs.1.7, P= 0.004), HCV viral load (6.4 vs.6.1 log10 IU/mL, P=0.02) and ALT level (206.8 vs.112.4 IU/L, P=0.05). Conclusions: An important part of the HIV-HCV co-infected patients had negative baseline predictors for the evolution of HCV infection; their therapeutical management must be conducted with special attention towards adherence and potential overlapping drug toxicities. High concentrations of plasma IP-10 are reliable markers for the severity of liver disease.

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APA: Copy

SULTANA, CAMELIA, ERSCOIU, SIMONA MANUELA, GRANCEA, CAMELIA, CEAUSU, EMANOIL, & RUTA, SIMONA. (2013). PREDICTORS OF CHRONIC HEPATITIS C EVOLUTION IN HIV CO-INFECTED PATIENTS FROM ROMANIA. HEPATITIS MONTHLY, 13(2), 0-0. SID. https://sid.ir/paper/306757/en

Vancouver: Copy

SULTANA CAMELIA, ERSCOIU SIMONA MANUELA, GRANCEA CAMELIA, CEAUSU EMANOIL, RUTA SIMONA. PREDICTORS OF CHRONIC HEPATITIS C EVOLUTION IN HIV CO-INFECTED PATIENTS FROM ROMANIA. HEPATITIS MONTHLY[Internet]. 2013;13(2):0-0. Available from: https://sid.ir/paper/306757/en

IEEE: Copy

CAMELIA SULTANA, SIMONA MANUELA ERSCOIU, CAMELIA GRANCEA, EMANOIL CEAUSU, and SIMONA RUTA, “PREDICTORS OF CHRONIC HEPATITIS C EVOLUTION IN HIV CO-INFECTED PATIENTS FROM ROMANIA,” HEPATITIS MONTHLY, vol. 13, no. 2, pp. 0–0, 2013, [Online]. Available: https://sid.ir/paper/306757/en

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