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Information Journal Paper

Title

OCCULT HEPATITIS B VIRUS INFECTION IN PATIENTS WITH CHRONIC HEPATITIS C TREATED WITH ANTIVIRAL THERAPY

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Abstract

 Background: Occult HEPATITIS B VIRUS INFECTION (OBI) is defined as the presence of HEPATITIS B VIRUS (HBV) DNA in the liver and/or in the serum of patients with negative results of hepatitis B s antigen (HBsAg) test with or without serological markers of previous viral exposure. The impact of OBI in patients with CHRONIC HEPATITIS C (CHC) is still unclear.Objectives: The Aim of this study was to assess OBI prevalence and its potential implications on treatment outcome in a cohort of patients with CHC underwent standard antiviral therapy.Patients and Methods: Baseline serum samples from 137 HBsAg-negative CHC patients treated with pegylated-interferon and ribavirin (73 Responders/74 Non Responders), were retrospectively analyzed for HBV status.Results: Seventy-three patients (53.3%) showed markers of previous exposure to HBV. HBV DNA was detected in 2 of 137 serum samples (1.5%), both carrying HBV antibodies. Liver biopsies and post-therapy sera were available for 35 patients (12 Responders/23 Non Responders). HBV DNA sequences were found in 13 of 35 specimens (37.1%), all of patients with HBV DNA negativity in basal and post-therapy serum samples. Among OBI-positive patients, 5 (38.5%) carried serological markers of HBV INFECTION. Regarding therapy outcome, in the OBI-positive group there were 5 of 13 (38.5%) sustained virological responders (SVR) compared to 7 of 22 (31.8%) in the OBI-negative one.Conclusions: Despite the high prevalence rate of liver HBV DNA in patients with CHC, SVR was not affected by occult HBV INFECTION.

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    APA: Copy

    CAVIGLIA, GIAN PAOLO, ABATE, MARIA LORENA, MANZINI, PAOLA, DANIELLE, FRANCA, CIANCIO, ALESSIA, ROSSO, CHIARA, PELLICANO, RINALDO, TOUSCOZ, GIOVANNI ANTONIO, RIZZETTO, MARIO. (2012). OCCULT HEPATITIS B VIRUS INFECTION IN PATIENTS WITH CHRONIC HEPATITIS C TREATED WITH ANTIVIRAL THERAPY. HEPATITIS MONTHLY, 12(11), 0-0. SID. https://sid.ir/paper/306775/en

    Vancouver: Copy

    CAVIGLIA GIAN PAOLO, ABATE MARIA LORENA, MANZINI PAOLA, DANIELLE FRANCA, CIANCIO ALESSIA, ROSSO CHIARA, PELLICANO RINALDO, TOUSCOZ GIOVANNI ANTONIO, RIZZETTO MARIO. OCCULT HEPATITIS B VIRUS INFECTION IN PATIENTS WITH CHRONIC HEPATITIS C TREATED WITH ANTIVIRAL THERAPY. HEPATITIS MONTHLY[Internet]. 2012;12(11):0-0. Available from: https://sid.ir/paper/306775/en

    IEEE: Copy

    GIAN PAOLO CAVIGLIA, MARIA LORENA ABATE, PAOLA MANZINI, FRANCA DANIELLE, ALESSIA CIANCIO, CHIARA ROSSO, RINALDO PELLICANO, GIOVANNI ANTONIO TOUSCOZ, MARIO RIZZETTO, “OCCULT HEPATITIS B VIRUS INFECTION IN PATIENTS WITH CHRONIC HEPATITIS C TREATED WITH ANTIVIRAL THERAPY,” HEPATITIS MONTHLY, vol. 12, no. 11, pp. 0–0, 2012, [Online]. Available: https://sid.ir/paper/306775/en

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