CYTOLOGIC COMPARISON BETWEEN MALIGNANT AND REGENERATIVE NODULES IN THE BACKGROUND OF CIRRHOSIS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GERAMIZADEH BITA; ASADI NAJMA; TABEI SEYED ZIYAODIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Hepatitis Monthly Year:2012 | Volume:12 | Issue:7 Page(s): 448-452

Download Full-Text

View:

248

Download:

295

Cites:

Information Journal Paper

Title

CYTOLOGIC COMPARISON BETWEEN MALIGNANT AND REGENERATIVE NODULES IN THE BACKGROUND OF CIRRHOSIS

Author(s)

GERAMIZADEH BITA | ASADI NAJMA | TABEI SEYED ZIYAODIN | Issue Writer Certificate

Keywords

CARCINOMA

HEPATOCELLULAR

LIVER CIRRHOSIS

BIOPSY

FINE-NEEDLE

Abstract

Background: Incidence of HEPATOCELLULAR CARCINOMA has been increased as the sixth most common cancer in the world. Improvement in imaging techniques has decreased the need for tissue confirmation in diagnosis of HEPATOCELLULAR CARCINOMA (HCC). Meanwhile, false negative and positive cases are present. Fine needle aspiration (FNA) BIOPSY can be helpful to identify well-differentiated HCCs with low risk of vascular invasion and better prognosis following transplantation.Objectives: We conducted this study to find useful criteria for cytological differential diagnosis between nodules of well differentiated HEPATOCELLULAR in the background of cirrhosis and pure cirrhotic regenerative nodules in cytology smears.Materials and Methods: 140 fine needle aspirations (FNA) of fresh cirrhotic hepatectomy specimens were studied (100 pure regenerative nodules and 40 HCC nodules). All slides were reviewed by two expert pathologists. The most useful criteria were selected and evaluated in 560 cytology smears stained by Pap and Wright methods.Results: None of the smears from cirrhotic patients showed mitosis, transgressing endothelium, eccentric nuclei, and scant cytoplasm, but thick nuclear membrane, spindle cells and abundant, thick and monotonous cytoplasm were found in many cases with cirrhosis. Large nucleoli (2%), multiple nucleoli (6%), increased N/C ratio (4%), and broad cores (2 %) were found very rarely in the smears of regenerative nodules, but they were present in 50%, 72.5%, 87%, and 77.5% of HCC nodules, respectively.Conclusions: Combination of cytologic criteria can be helpful for differential diagnosis between HCC and regenerative nodules.

Cites

No record.

References

No record.

Cite

APA: Copy

GERAMIZADEH, BITA, ASADI, NAJMA, & TABEI, SEYED ZIYAODIN. (2012). CYTOLOGIC COMPARISON BETWEEN MALIGNANT AND REGENERATIVE NODULES IN THE BACKGROUND OF CIRRHOSIS. HEPATITIS MONTHLY, 12(7), 448-452. SID. https://sid.ir/paper/306785/en

Vancouver: Copy

GERAMIZADEH BITA, ASADI NAJMA, TABEI SEYED ZIYAODIN. CYTOLOGIC COMPARISON BETWEEN MALIGNANT AND REGENERATIVE NODULES IN THE BACKGROUND OF CIRRHOSIS. HEPATITIS MONTHLY[Internet]. 2012;12(7):448-452. Available from: https://sid.ir/paper/306785/en

IEEE: Copy

BITA GERAMIZADEH, NAJMA ASADI, and SEYED ZIYAODIN TABEI, “CYTOLOGIC COMPARISON BETWEEN MALIGNANT AND REGENERATIVE NODULES IN THE BACKGROUND OF CIRRHOSIS,” HEPATITIS MONTHLY, vol. 12, no. 7, pp. 448–452, 2012, [Online]. Available: https://sid.ir/paper/306785/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops