THE REDUCED PREDICTIVE VALUE OF INTERLEUKIN 28B GENE POLYMORPHISMS IN A COHORT OF PATIENTS WITH THYROIDITIS DEVELOPED DURING ANTIVIRAL THERAPY FOR CHRONIC HEPATITIS C: A PRELIMINARY STUDY

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TRAN HUY A; JONES TRACEY L; IANNA ELIZABETH A; GIBSON ROBERT A; REEVES GLENN EM

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Journal: Hepatitis Monthly Year:2012 | Volume:12 | Issue:8 Page(s): 1-7

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Title

THE REDUCED PREDICTIVE VALUE OF INTERLEUKIN 28B GENE POLYMORPHISMS IN A COHORT OF PATIENTS WITH THYROIDITIS DEVELOPED DURING ANTIVIRAL THERAPY FOR CHRONIC HEPATITIS C: A PRELIMINARY STUDY

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Keywords

POLYMORPHISM

GENETIC

HEPATITIS C

THYROIDITIS

Abstract

Background: Single nucleotide POLYMORPHISM in the interleukin28B (IL28B) gene was recently shown to be associated with a significant increase in response to interferon-α and ribavirin treatment in patients with chronic HEPATITIS C. Similarly, thyroid disease (TD) occurring during treatment confer an improved sustained virologic response (SVR).Objectives: To determine the role of IL28B genotypes in a cohort of HEPATITIS C patients who develop TD during treatment and its relationship to SVR.Patients and Methods: IL28B gene profiles including rs12979860, rs12980275 and rs 8099917 and their genotypes were determined in a cohort of 23 HEPATITIS C patients who developed TD during treatment and their relationship to SVR.Results: Out of 23 studies cases, 19 has one or more favorable genotypes, of which 15 (78.9%) achieved SVR. Eleven has all three unfavorable genotypes and yet achieved 72.7% SVR. The presence of more than one favorable genotype only correctly predicts SVR vs. non- SVR in ~50% of cases, i.e. by chance.Conclusions: Despite the small number of subjects, the presence of one or more unfavorable IL28B genotype does not portend a poor SVR prognostic outcome. This suggests that TD in this clinical context may be a critical factor in the achievement of SVR, probably above that of the GENETIC predisposition.

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APA: Copy

TRAN, HUY A, JONES, TRACEY L, IANNA, ELIZABETH A, GIBSON, ROBERT A, & REEVES, GLENN EM. (2012). THE REDUCED PREDICTIVE VALUE OF INTERLEUKIN 28B GENE POLYMORPHISMS IN A COHORT OF PATIENTS WITH THYROIDITIS DEVELOPED DURING ANTIVIRAL THERAPY FOR CHRONIC HEPATITIS C: A PRELIMINARY STUDY. HEPATITIS MONTHLY, 12(8), 1-7. SID. https://sid.ir/paper/306797/en

Vancouver: Copy

TRAN HUY A, JONES TRACEY L, IANNA ELIZABETH A, GIBSON ROBERT A, REEVES GLENN EM. THE REDUCED PREDICTIVE VALUE OF INTERLEUKIN 28B GENE POLYMORPHISMS IN A COHORT OF PATIENTS WITH THYROIDITIS DEVELOPED DURING ANTIVIRAL THERAPY FOR CHRONIC HEPATITIS C: A PRELIMINARY STUDY. HEPATITIS MONTHLY[Internet]. 2012;12(8):1-7. Available from: https://sid.ir/paper/306797/en

IEEE: Copy

HUY A TRAN, TRACEY L JONES, ELIZABETH A IANNA, ROBERT A GIBSON, and GLENN EM REEVES, “THE REDUCED PREDICTIVE VALUE OF INTERLEUKIN 28B GENE POLYMORPHISMS IN A COHORT OF PATIENTS WITH THYROIDITIS DEVELOPED DURING ANTIVIRAL THERAPY FOR CHRONIC HEPATITIS C: A PRELIMINARY STUDY,” HEPATITIS MONTHLY, vol. 12, no. 8, pp. 1–7, 2012, [Online]. Available: https://sid.ir/paper/306797/en

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