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Title

DRUG-RELATED MUTATIONAL PATTERNS IN HEPATITIS B VIRUS (HBV) REVERSE TRANSCRIPTASE PROTEINS FROM IRANIAN TREATMENT-NAIVE CHRONIC HBV PATIENTS

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Abstract

 Background: Immunomodulators and Nucleotide analogues have been used globally for the dealing of chronic HEPATITIS B VIRUS (HBV) infection. However, the development of drug resistance is a major limitation to their long-term effectiveness.Objectives: The aim of this study was to characterize the HEPATITIS B VIRUS reverse transcriptase (RT) protein variations among IRANian chronic HBV carriers who did not receive any antiviral treatments.Materials and Methods: HEPATITIS B VIRUS partial RT genes from 325 chronic in active carrier patients were amplified and directly sequenced.Nucleotide/amino acid substitutions were identified compared to the sequences obtained from the database.Results: All strains belonging to genotype D.365 amino-acid substitutions were found. Mutations related to lamivudine, adefovir, telbivudine, and entecavir occurred in (YMDD) 4% (n=13), (SVQ) 17.23% (n=56), (M204I/V+L180M) 2.45% (n=8) and (M204I) 2.76% (n=9) of patients, respectively.Conclusions: RT mutants do occur naturally and could be found in HBV carriers who have never received antiviral THERAPY. However, mutations related to drug resistance in IRANian treatment-naïve chronic HBV patients were found to be higher than other studies published formerly. Chronic HBV patients should be monitored closely prior the commencement of THERAPY to achieve the best regimen option.

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    APA: Copy

    MAHABADI, MOSTAFA, NOROUZI, MEHDI, ALAVIAN, SEYED MOAYED, SAMIMI RAD, KATAYOUN, MOKHTARI AZAD, TALAT, SABERFAR, ESMAEIL, MAHMOODI, MAHMOOD, RAMEZANI, FATEMEH, KARIMZADEH, HADI, MALEKZADEH, REZA, MONTAZERI, GHODRAT, NEJATIZADEH, AZIM, ZIAEE, MASOUD, ABEDI, FARSHID, ATAEI, BEHROOZ, YARAN, MAJID, SAYAD, BABAK, SOMI, MOHAMMAD HOSSEIN, SARIZADEH, GHOLAMREZA, SANEI MOGHADDAM, ISMAIL, MANSOUR GHANAEI, FARIBORZ, RAFATPANAH, HOUSHANG, POURHOSEINGHOLI, MOHAMAD AMIN, KEYVANI, HOSSEIN, KALANTARI, EBRAHIM, SABERI FIROOZI, MEHDI, JUDAKI, MOHAMMAD ALI, GHAMARI, SHIVA, DARAM, MARYAM, FAZELI, ZEINAB, GOODARZI, ZAHRA, KHEDIVE, ABOLFAZL, MORADI, ABDOLVAHAB, & JAZAYERI, SEYED MOHAMMAD. (2013). DRUG-RELATED MUTATIONAL PATTERNS IN HEPATITIS B VIRUS (HBV) REVERSE TRANSCRIPTASE PROTEINS FROM IRANIAN TREATMENT-NAIVE CHRONIC HBV PATIENTS. HEPATITIS MONTHLY, 13(1), 0-0. SID. https://sid.ir/paper/306868/en

    Vancouver: Copy

    MAHABADI MOSTAFA, NOROUZI MEHDI, ALAVIAN SEYED MOAYED, SAMIMI RAD KATAYOUN, MOKHTARI AZAD TALAT, SABERFAR ESMAEIL, MAHMOODI MAHMOOD, RAMEZANI FATEMEH, KARIMZADEH HADI, MALEKZADEH REZA, MONTAZERI GHODRAT, NEJATIZADEH AZIM, ZIAEE MASOUD, ABEDI FARSHID, ATAEI BEHROOZ, YARAN MAJID, SAYAD BABAK, SOMI MOHAMMAD HOSSEIN, SARIZADEH GHOLAMREZA, SANEI MOGHADDAM ISMAIL, MANSOUR GHANAEI FARIBORZ, RAFATPANAH HOUSHANG, POURHOSEINGHOLI MOHAMAD AMIN, KEYVANI HOSSEIN, KALANTARI EBRAHIM, SABERI FIROOZI MEHDI, JUDAKI MOHAMMAD ALI, GHAMARI SHIVA, DARAM MARYAM, FAZELI ZEINAB, GOODARZI ZAHRA, KHEDIVE ABOLFAZL, MORADI ABDOLVAHAB, JAZAYERI SEYED MOHAMMAD. DRUG-RELATED MUTATIONAL PATTERNS IN HEPATITIS B VIRUS (HBV) REVERSE TRANSCRIPTASE PROTEINS FROM IRANIAN TREATMENT-NAIVE CHRONIC HBV PATIENTS. HEPATITIS MONTHLY[Internet]. 2013;13(1):0-0. Available from: https://sid.ir/paper/306868/en

    IEEE: Copy

    MOSTAFA MAHABADI, MEHDI NOROUZI, SEYED MOAYED ALAVIAN, KATAYOUN SAMIMI RAD, TALAT MOKHTARI AZAD, ESMAEIL SABERFAR, MAHMOOD MAHMOODI, FATEMEH RAMEZANI, HADI KARIMZADEH, REZA MALEKZADEH, GHODRAT MONTAZERI, AZIM NEJATIZADEH, MASOUD ZIAEE, FARSHID ABEDI, BEHROOZ ATAEI, MAJID YARAN, BABAK SAYAD, MOHAMMAD HOSSEIN SOMI, GHOLAMREZA SARIZADEH, ISMAIL SANEI MOGHADDAM, FARIBORZ MANSOUR GHANAEI, HOUSHANG RAFATPANAH, MOHAMAD AMIN POURHOSEINGHOLI, HOSSEIN KEYVANI, EBRAHIM KALANTARI, MEHDI SABERI FIROOZI, MOHAMMAD ALI JUDAKI, SHIVA GHAMARI, MARYAM DARAM, ZEINAB FAZELI, ZAHRA GOODARZI, ABOLFAZL KHEDIVE, ABDOLVAHAB MORADI, and SEYED MOHAMMAD JAZAYERI, “DRUG-RELATED MUTATIONAL PATTERNS IN HEPATITIS B VIRUS (HBV) REVERSE TRANSCRIPTASE PROTEINS FROM IRANIAN TREATMENT-NAIVE CHRONIC HBV PATIENTS,” HEPATITIS MONTHLY, vol. 13, no. 1, pp. 0–0, 2013, [Online]. Available: https://sid.ir/paper/306868/en

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