A COMPREHENSIVE LONG-TERM PROGNOSIS OF CHRONIC HEPATITIS C PATIENTS WITH ANTIVIRAL THERAPY: A META-ANALYSIS OF STUDIES FROM 2008 TO 2014

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WEN YA; ZHENG XIANG; TAN DEMING

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Hepatitis Monthly Year:2015 | Volume:15 | Issue:5 Page(s): 0-0

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Title

A COMPREHENSIVE LONG-TERM PROGNOSIS OF CHRONIC HEPATITIS C PATIENTS WITH ANTIVIRAL THERAPY: A META-ANALYSIS OF STUDIES FROM 2008 TO 2014

Author(s)

WEN YA | ZHENG XIANG | TAN DEMING | Issue Writer Certificate

Keywords

CHRONIC HEPATITIS C

META-ANALYSIS

ANTIVIRAL THERAPY

Abstract

Context: Attaining a sustained virological response with ANTIVIRAL THERAPY is a sign of clinical cure for CHRONIC HEPATITIS C patients. The aim of this META-ANALYSIS was to evaluate the long-term efficiency and outcome of ANTIVIRAL THERAPY in patients with hepatitis C who attained a sustained virological response.Evidence Acquisition: A literature search was performed on published articles between January 2008 and February 2014. Patients with Hepatitis C who received interferon with or without ribavirin therapy were enrolled. Relative risks were estimated using either fixed or random effect models.Results: Patients who attained sustained virological response had a less risk (85%) for all-cause mortality and about 63% reduced risk of hepatocellular carcinoma incidence than those who did not achieve sustained virological response. Based on deeply analysis, the stage of liver fibrosis was a risk factor at baseline for the incidence of hepatocellular carcinoma.Conclusions: Sustained virological response can reduce all-cause mortality and the incidence of hepatocellular carcinoma of patients with hepatitis C. Advanced liver fibrosis is still a risk factor for the incidence of hepatocellular carcinoma, in spite of hepatitis C patients attained a sustained virological response.

Cites

NEXT STEPS TOWARD ERADICATION OF HEPATITIS C IN THE ERA OF DIRECT ACTING ANTIVIRALS (REVIEW ARTICLE)

References

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APA: Copy

WEN, YA, ZHENG, XIANG, & TAN, DEMING. (2015). A COMPREHENSIVE LONG-TERM PROGNOSIS OF CHRONIC HEPATITIS C PATIENTS WITH ANTIVIRAL THERAPY: A META-ANALYSIS OF STUDIES FROM 2008 TO 2014. HEPATITIS MONTHLY, 15(5), 0-0. SID. https://sid.ir/paper/306881/en

Vancouver: Copy

WEN YA, ZHENG XIANG, TAN DEMING. A COMPREHENSIVE LONG-TERM PROGNOSIS OF CHRONIC HEPATITIS C PATIENTS WITH ANTIVIRAL THERAPY: A META-ANALYSIS OF STUDIES FROM 2008 TO 2014. HEPATITIS MONTHLY[Internet]. 2015;15(5):0-0. Available from: https://sid.ir/paper/306881/en

IEEE: Copy

YA WEN, XIANG ZHENG, and DEMING TAN, “A COMPREHENSIVE LONG-TERM PROGNOSIS OF CHRONIC HEPATITIS C PATIENTS WITH ANTIVIRAL THERAPY: A META-ANALYSIS OF STUDIES FROM 2008 TO 2014,” HEPATITIS MONTHLY, vol. 15, no. 5, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/306881/en

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