EFFICACY AND TOLERABILITY OF PEG INTERFERON ALPHA-2A AND PEG INTERFERON ALPHA-2B IN IRANIAN PATIENTS WITH CHRONIC HEPATITIS C

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POURESMAEELI MAHDIYAR; ALAVIAN SEYED MOAYED; KESHVARI MARYAM; SALIMI SHIMA; MEHRNOUSH LEILA

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Journal: Hepatitis Monthly Year:2015 | Volume:15 | Issue:9 Page(s): 0-0

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Title

EFFICACY AND TOLERABILITY OF PEG INTERFERON ALPHA-2A AND PEG INTERFERON ALPHA-2B IN IRANIAN PATIENTS WITH CHRONIC HEPATITIS C

Author(s)

Keywords

HEPATITIS C

IRAN

PEG INTERFERON ALFA-2A

PEG INTERFERON ALFA-2B

Abstract

Background: Nearly 0.5% of IRANians are infected with HCV. Peginterferon-alpha-2a and Peginterferon-alpha-2b are the two available types of interferon for the treatment of HEPATITIS C. Comparing the results of these two treatments is still a challenge.Objectives: The aim of this study was to compare the results of Peginterferon-alpha-2a and Peginterferon-alpha-2b in IRANian patients with chronic HEPATITIS C.Patients and Methods: 289 patients with chronic HEPATITIS C attending Tehran HEPATITIS Center (THC) and HEPATITIS Clinic of Tehran Blood Transfusion Organization (TBTO) from January 2008 to April 2013 and treated with combination of Peginterferon-alpha-2a or Peginterferon-alpha-2b plus Ribavirin were enrolled in this retrospective cross-sectional study. Treatment response and side effects were compared.Results: Among all naive patients, 82.0% achieved SVR, 5.4% were resistant to therapy and 11.0% withdrew the treatment. Relapse was seen in 12.2% of naive patients who finished the course of treatment. RVR and EVR were seen in 67.7% and 90.6% of naive patients, respectively. Patients divided into two groups. Group A consists of 247 patients treated with Peginterferon-alpha-2a and group B 42 patients treated with Peginterferon-alpha-2b. No significant difference in treatment response was observed between naive patients of the two groups. The rates of arthralgia/myalgia, alopecia, pruritus, insomnia, dyspnea and anorexia were higher in group A and the rates of dermal problems, coryza and bleeding were higher in group B. In a subgroup analysis, the two kinds of Peginterferon-alpha-2a available in IRAN were compared. Rapid and early viral responses and relapse rates were lower in the one made in IRAN and the long-term responses were not different. The rates of arthralgia/myalgia, fever, alopecia, pruritus, insomnia, dyspnea, anorexia, cough, headache and abdominal pain were higher and the rates of irritability and coryza were lower in the one made in IRAN.Conclusions: There was no significant difference in the efficacy of Peginterferon-alpha-2a and Peginterferon-alpha-2b in IRANian patients. Physicians might choose the treatment regimen for every individual concerning the differences in side effects of Peg interferons.

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APA: Copy

POURESMAEELI, MAHDIYAR, ALAVIAN, SEYED MOAYED, KESHVARI, MARYAM, SALIMI, SHIMA, & MEHRNOUSH, LEILA. (2015). EFFICACY AND TOLERABILITY OF PEG INTERFERON ALPHA-2A AND PEG INTERFERON ALPHA-2B IN IRANIAN PATIENTS WITH CHRONIC HEPATITIS C. HEPATITIS MONTHLY, 15(9), 0-0. SID. https://sid.ir/paper/306937/en

Vancouver: Copy

POURESMAEELI MAHDIYAR, ALAVIAN SEYED MOAYED, KESHVARI MARYAM, SALIMI SHIMA, MEHRNOUSH LEILA. EFFICACY AND TOLERABILITY OF PEG INTERFERON ALPHA-2A AND PEG INTERFERON ALPHA-2B IN IRANIAN PATIENTS WITH CHRONIC HEPATITIS C. HEPATITIS MONTHLY[Internet]. 2015;15(9):0-0. Available from: https://sid.ir/paper/306937/en

IEEE: Copy

MAHDIYAR POURESMAEELI, SEYED MOAYED ALAVIAN, MARYAM KESHVARI, SHIMA SALIMI, and LEILA MEHRNOUSH, “EFFICACY AND TOLERABILITY OF PEG INTERFERON ALPHA-2A AND PEG INTERFERON ALPHA-2B IN IRANIAN PATIENTS WITH CHRONIC HEPATITIS C,” HEPATITIS MONTHLY, vol. 15, no. 9, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/306937/en

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