RAPID VIROLOGICAL RESPONSE REPRESENTS THE HIGHEST PREDICTION FACTOR OF RESPONSE TO ANTIVIRAL TREATMENT IN HCV-RELATED CHRONIC HEPATITIS: A MULTICENTER RETROSPECTIVE STUDY

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FEDERICO ALESSANDRO; MASARONE MARIO; ROMANO MARCO; DALLIO MARCELLO; ROSATO VALERIO; PERSICO MARCELLO

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Journal: Hepatitis Monthly Year:2015 | Volume:15 | Issue:6 Page(s): 0-0

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Title

RAPID VIROLOGICAL RESPONSE REPRESENTS THE HIGHEST PREDICTION FACTOR OF RESPONSE TO ANTIVIRAL TREATMENT IN HCV-RELATED CHRONIC HEPATITIS: A MULTICENTER RETROSPECTIVE STUDY

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Keywords

ANTIVIRAL AGENTS

HEPATITIS C

PEGYLATED INTERFERON SA

RETROSPECTIVE STUDIES

RIBAVIRIN

Abstract

Background: Standard [i.e. pegylated interferon (Peg-IFN) + RIBAVIRIN] treatment of HEPATITIS C virus (HCV)-related chronic hepatitis is associated with a sustained virological response (SVR) in 50 - 90% of patients. A rapid virological response (RVR) (i.e. negative HCV-RNA after 4 weeks of treatment) predicts SVR in almost 90% of patients.Objectives: The main aim of this study was to assess the strength of RVR, as a predictive factor of antiviral treatment response.Patients and Methods: Using univariate and multivariate analysis, we retrospectively evaluated biochemical, metabolic, genetic and viral variables that might affect both RVR and SVR to Peg-IFN plus RIBAVIRIN, in 315 consecutive outpatients affected by HCV-related chronic hepatitis.Results: At univariate analysis, staging, body mass index, RVR, genotype and viral load were significantly related to SVR (P < 0.001). At multivariate analysis, RVR and genotype remained significant (P < 0.00001). The RVR had a predictive value of 83%. At univariate and multivariate analyses, diabetes (P = 0.003), genotype 2 (P = 0.000) and HCV-RNA values (P = 0.016) were independent predictors of RVR, even though at multivariate analyses, only genotype 2 was significantly related to RVR. When we stratified patients, according to genotype, no laboratory or clinical factors were predictive of RVR in genotype 1 patients at either univariate or multivariate analysis. In genotype 2 patients, staging (P = 0.029) and diabetes (P = 0.001) were the only significant predictors of RVR at univariate analyses, whereas no factor was independently related to RVR, at multivariate analysis.Conclusions: The RVR is the strongest factor of SVR and infection with HCV genotype 2 is significantly associated with RVR. Neither biochemical and/or metabolic factors seem to exert influence on RVR.

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APA: Copy

FEDERICO, ALESSANDRO, ROMANO, MARCO, DALLIO, MARCELLO, ROSATO, VALERIO, & PERSICO, MARCELLO. (2015). RAPID VIROLOGICAL RESPONSE REPRESENTS THE HIGHEST PREDICTION FACTOR OF RESPONSE TO ANTIVIRAL TREATMENT IN HCV-RELATED CHRONIC HEPATITIS: A MULTICENTER RETROSPECTIVE STUDY. HEPATITIS MONTHLY, 15(6), 0-0. SID. https://sid.ir/paper/306947/en

Vancouver: Copy

FEDERICO ALESSANDRO, ROMANO MARCO, DALLIO MARCELLO, ROSATO VALERIO, PERSICO MARCELLO. RAPID VIROLOGICAL RESPONSE REPRESENTS THE HIGHEST PREDICTION FACTOR OF RESPONSE TO ANTIVIRAL TREATMENT IN HCV-RELATED CHRONIC HEPATITIS: A MULTICENTER RETROSPECTIVE STUDY. HEPATITIS MONTHLY[Internet]. 2015;15(6):0-0. Available from: https://sid.ir/paper/306947/en

IEEE: Copy

ALESSANDRO FEDERICO, MARCO ROMANO, MARCELLO DALLIO, VALERIO ROSATO, and MARCELLO PERSICO, “RAPID VIROLOGICAL RESPONSE REPRESENTS THE HIGHEST PREDICTION FACTOR OF RESPONSE TO ANTIVIRAL TREATMENT IN HCV-RELATED CHRONIC HEPATITIS: A MULTICENTER RETROSPECTIVE STUDY,” HEPATITIS MONTHLY, vol. 15, no. 6, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/306947/en

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