GENOMIC DIVERSITY OF HEPATITIS B VIRUS INFECTION ASSOCIATED WITH FULMINANT HEPATITIS B DEVELOPMENT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MINA THOMAS; AMINI BAVIL OLYAEE SAMAD; TACKE FRANK; MAES PIET; RANST MARC VAN; POURKARIM MAHMOUD REZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Hepatitis Monthly Year:2015 | Volume:15 | Issue:6 Page(s): 0-0

Download Full-Text

View:

288

Download:

258

Cites:

Information Journal Paper

Title

GENOMIC DIVERSITY OF HEPATITIS B VIRUS INFECTION ASSOCIATED WITH FULMINANT HEPATITIS B DEVELOPMENT

Author(s)

Keywords

HEPATITIS B VIRUS

LIVER FAILURE

ACUTE

HUMAN GENOME PROJECT

Abstract

Context: After five decades of HEPATITIS B VIRUS (HBV) vaccine discovery, HBV is still a major public health problem. Due to the high genetic diversity of HBV and selective pressure of the host immune system, intra-host evolution of this virus in different clinical manifestations is a hot topic of research. HBV infection causes a range of clinical manifestations from ACUTE to chronic infection, cirrhosis and hepatocellular carcinoma. Among all forms of HBV infection manifestations, fulminant hepatitis B infection possesses the highest fatality rate. Almost 1% of the ACUTEly infected patients develop fulminant hepatitis B, in which the mortality rate is around 70%.Evidence Acquisition: All published papers deposited in Genbank, on the topic of fulminant hepatitis were reviewed and their virological aspects were investigated. In this review, we highlight the genomic diversity of HBV reported from patients with fulminant HBV infection.Results: The most commonly detected diversities affect regulatory motifs of HBV in the core and S region, indicating that these alterations may convert the virus to an aggressive strain. Moreover, mutations at T-cell and B-cell epitopes located in pre-S1 and pre-S2 proteins may lead to an immune evasion of the virus, likely favoring a more severe clinical course of infection. Furthermore, point and frame shift mutations in the core region increase the viral replication of HBV and help virus to evade from immune system and guarantee its persistence.Conclusions: Fulminant hepatitis B is associated with distinct mutational patterns of HBV, underlining that genomic diversity of the virus is an important factor determining its pathogenicity.

Cites

No record.

References

No record.

Cite

APA: Copy

MINA, THOMAS, AMINI BAVIL OLYAEE, SAMAD, TACKE, FRANK, MAES, PIET, RANST, MARC VAN, & POURKARIM, MAHMOUD REZA. (2015). GENOMIC DIVERSITY OF HEPATITIS B VIRUS INFECTION ASSOCIATED WITH FULMINANT HEPATITIS B DEVELOPMENT. HEPATITIS MONTHLY, 15(6), 0-0. SID. https://sid.ir/paper/306948/en

Vancouver: Copy

MINA THOMAS, AMINI BAVIL OLYAEE SAMAD, TACKE FRANK, MAES PIET, RANST MARC VAN, POURKARIM MAHMOUD REZA. GENOMIC DIVERSITY OF HEPATITIS B VIRUS INFECTION ASSOCIATED WITH FULMINANT HEPATITIS B DEVELOPMENT. HEPATITIS MONTHLY[Internet]. 2015;15(6):0-0. Available from: https://sid.ir/paper/306948/en

IEEE: Copy

THOMAS MINA, SAMAD AMINI BAVIL OLYAEE, FRANK TACKE, PIET MAES, MARC VAN RANST, and MAHMOUD REZA POURKARIM, “GENOMIC DIVERSITY OF HEPATITIS B VIRUS INFECTION ASSOCIATED WITH FULMINANT HEPATITIS B DEVELOPMENT,” HEPATITIS MONTHLY, vol. 15, no. 6, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/306948/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops