IMPACT OF THE IL-10 PROMOTER GENE POLYMORPHISMS IN THE SEVERITY OF CHRONIC HEPATITIS B INFECTION

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GHALEH BAGHI SAHAND; ALAVIAN SEYED MOAYED; MEHRNOUSH LEILA; SALIMI SHIMA

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Journal Paper

Paper Information

Journal: Hepatitis Monthly Year:2015 | Volume:15 | Issue:7 Page(s): 0-0

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Title

IMPACT OF THE IL-10 PROMOTER GENE POLYMORPHISMS IN THE SEVERITY OF CHRONIC HEPATITIS B INFECTION

Author(s)

GHALEH BAGHI SAHAND | ALAVIAN SEYED MOAYED | MEHRNOUSH LEILA | SALIMI SHIMA | Issue Writer Certificate

Keywords

GENOTYPE

INTERLEUKIN-10

POLYMORPHISM

GENETIC

PROMOTER REGIONS

GENETIC

LIVER CIRRHOSIS

Abstract

ckground: INTERLEUKIN-10 (IL-10) is an important anti-inflammatory cytokine. The POLYMORPHISMs of its promoter gene have been considered to be related with the chronicity of hepatitis B infection.Objectives: The aim of this study was to evaluate the POLYMORPHISMs at different positions in the IL-10 promoter gene in patients with chronic hepatitis B.Patients and Methods: Totally, 166 patients with chronic hepatitis B infection were enrolled. GENOTYPEs at different positions (i.e. -819, - 592, and - 1082) in the IL-10 gene promoter were determined.Results: The C/A GENOTYPE at position -592, C/T GENOTYPE at position -819, and GCC/ATA haplotype of the IL-10 gene promoter were significantly more common in the patients with cirrhosis. The GENOTYPEs were significantly different between the hepatitis B e antigen (HBeAg)-negative and HBeAg-positive patients at position -592 (C/A and C/C), position -819 (C/C and C/T), and position -1082 (A/A and G/A).Conclusions: Some IL-10 promoter gene POLYMORPHISMs predisposed the infected hepatitis B virus cases to cirrhosis in our study population.

Cites

ASSOCIATION BETWEEN IL-10 GENE PROMOTER POLYMORPHISMS (-592 A/C, -819 T/C, -1082 A/G) AND SUSCEPTIBILITY TO HBV INFECTION IN AN IRANIAN POPULATION

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APA: Copy

GHALEH BAGHI, SAHAND, ALAVIAN, SEYED MOAYED, MEHRNOUSH, LEILA, & SALIMI, SHIMA. (2015). IMPACT OF THE IL-10 PROMOTER GENE POLYMORPHISMS IN THE SEVERITY OF CHRONIC HEPATITIS B INFECTION. HEPATITIS MONTHLY, 15(7), 0-0. SID. https://sid.ir/paper/306955/en

Vancouver: Copy

GHALEH BAGHI SAHAND, ALAVIAN SEYED MOAYED, MEHRNOUSH LEILA, SALIMI SHIMA. IMPACT OF THE IL-10 PROMOTER GENE POLYMORPHISMS IN THE SEVERITY OF CHRONIC HEPATITIS B INFECTION. HEPATITIS MONTHLY[Internet]. 2015;15(7):0-0. Available from: https://sid.ir/paper/306955/en

IEEE: Copy

SAHAND GHALEH BAGHI, SEYED MOAYED ALAVIAN, LEILA MEHRNOUSH, and SHIMA SALIMI, “IMPACT OF THE IL-10 PROMOTER GENE POLYMORPHISMS IN THE SEVERITY OF CHRONIC HEPATITIS B INFECTION,” HEPATITIS MONTHLY, vol. 15, no. 7, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/306955/en

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