ASSOCIATION BETWEEN IL-10 GENE PROMOTER POLYMORPHISMS (-592 A/C, -819 T/C, -1082 A/G) AND SUSCEPTIBILITY TO HBV INFECTION IN AN IRANIAN POPULATION

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MOUDI BITA; HEIDARI ZAHRA; MAHMOUDZADEH SAGHEB HAMIDREZA; HASHEMI MOHAMMAD; METANAT MALIHEH; KHOSRAVI SOHEILA; FARROKH PARISA

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Journal: Hepatitis Monthly Year:2016 | Volume:16 | Issue:2 Page(s): 0-0

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Title

ASSOCIATION BETWEEN IL-10 GENE PROMOTER POLYMORPHISMS (-592 A/C, -819 T/C, -1082 A/G) AND SUSCEPTIBILITY TO HBV INFECTION IN AN IRANIAN POPULATION

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Keywords

CHRONIC HEPATITIS B

INTERLEUKIN-10

SINGLE NUCLEOTIDE POLYMORPHISM

Abstract

Background: IL-10 can play a vital role in immune response against HBV. Three biallelic SNPs from the transcription start site control the transcription of the IL-10 gene. An association between susceptibility to HBV and IL-10 polymorphisms has been suggested in patients with HBV infection.Objectives: The present study was designed to study the association between polymorphisms in INTERLEUKIN-10 (-1082 A/G, -819 T/C and -592 A/C) promoter gene and CHRONIC HEPATITIS B virus (HBV) infection.Patients and Methods: 221 chronically infected patients and 200 healthy control subjects were enrolled in the study. Three biallelic (-1082 A/G, -819 T/C and -592 A/C) polymorphisms in the IL-10 promoter gene were determined by PCR-RFLP method.Results: Persistent HBV infection was associated with IL-10-1082 AG (P=0.001) and GG (P=0.004) genotypes and G (P=0.000) allele. IL-10-819 T/C and -592 A/C genotype and allele frequencies did not show any correlation with the risk of CHRONIC HEPATITIS B infection.Conclusions: These results suggest that polymorphisms in INTERLEUKIN-10 gene promoter influence clinical outcome of HBV infection and susceptibility to HBV infection.

Cites

The relationship between L‑ leucine‑ 7‑ amido ‑ 4‑ methyl coumarin 1 gene polymorphism and susceptibility to the chronic hepatitis B virus infection in an Iranian population

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APA: Copy

MOUDI, BITA, HEIDARI, ZAHRA, MAHMOUDZADEH SAGHEB, HAMIDREZA, HASHEMI, MOHAMMAD, METANAT, MALIHEH, KHOSRAVI, SOHEILA, & FARROKH, PARISA. (2016). ASSOCIATION BETWEEN IL-10 GENE PROMOTER POLYMORPHISMS (-592 A/C, -819 T/C, -1082 A/G) AND SUSCEPTIBILITY TO HBV INFECTION IN AN IRANIAN POPULATION. HEPATITIS MONTHLY, 16(2), 0-0. SID. https://sid.ir/paper/306972/en

Vancouver: Copy

MOUDI BITA, HEIDARI ZAHRA, MAHMOUDZADEH SAGHEB HAMIDREZA, HASHEMI MOHAMMAD, METANAT MALIHEH, KHOSRAVI SOHEILA, FARROKH PARISA. ASSOCIATION BETWEEN IL-10 GENE PROMOTER POLYMORPHISMS (-592 A/C, -819 T/C, -1082 A/G) AND SUSCEPTIBILITY TO HBV INFECTION IN AN IRANIAN POPULATION. HEPATITIS MONTHLY[Internet]. 2016;16(2):0-0. Available from: https://sid.ir/paper/306972/en

IEEE: Copy

BITA MOUDI, ZAHRA HEIDARI, HAMIDREZA MAHMOUDZADEH SAGHEB, MOHAMMAD HASHEMI, MALIHEH METANAT, SOHEILA KHOSRAVI, and PARISA FARROKH, “ASSOCIATION BETWEEN IL-10 GENE PROMOTER POLYMORPHISMS (-592 A/C, -819 T/C, -1082 A/G) AND SUSCEPTIBILITY TO HBV INFECTION IN AN IRANIAN POPULATION,” HEPATITIS MONTHLY, vol. 16, no. 2, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/306972/en

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