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Information Journal Paper

Title

CLINICAL TRIAL OF MEDROXYPROGESTRONE ACETATE ON MENSTUREAL BLOOD LOSS AND QUALITYOF LIFE IN WOMEN WITH MENORRHAGIA

Pages

  21-32

Abstract

 Background and Objective: Severe menstrual bleeding is a leading cause of poor QUALITY OF LIFE and iron deficiency anemia in reproductive aged women. The aim of this study was to investigate the efficacy and acceptability of long-term use of medroxyprogestrone acetate in menorrhagia management.Materials and Methods: In a pre-post trial, 44 eligible women were allocated to long term medroxyprogestrone acetate treatment (for 3 consecutive cycles). Changes in duration and amount of bleeding, QUALITY OF LIFE and also hemoglobin and ferritin values were checked out and compared before and after treatment.Results: Medroxyprogestrone acetate reduced mean PBLAC score from 220.15 (±74.99) in control cycle to 108.81 (±74.98) in third cycle (p<0.0001). Hemoglobin increased from 12.24 (±0.89) to 13.21 (±0.88) g/dl and ferritin increased from 13.38 (±6.81) to 30.85 (±8.51) ng/dl (p<0/0001). Duration of menstrual bleeding decreased from 8.4 (±1.47) days to 8.06 (±1.53) days (p=0.001). Medroxyprogestrone acetate reduced mean MQ score from 66.46 (±13.82) to 14.13 (±7.98) (p<0.0001). SF-36 QUALITY OF LIFE scores increased in all aspects (except for bodily pain) (p<0.0001).Conclusion: Our results showed that long term use of MPA is an effective treatment for idiopathic menorrhagia in terms of menstrual blood loss, hematologic indices and QUALITY OF LIFE (p<0.05) and observed complications are not significant. This makes long-term MPA a favored drug choice in idiopathic menorrhagia management in premenopausal women.

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    APA: Copy

    MOUKHAH, SOMAYEH, GOSHTASEBI, AZITA, & MOAYED MOHSENI, SAKINEH. (2011). CLINICAL TRIAL OF MEDROXYPROGESTRONE ACETATE ON MENSTUREAL BLOOD LOSS AND QUALITYOF LIFE IN WOMEN WITH MENORRHAGIA. DANESHVAR MEDICINE, 18(93), 21-32. SID. https://sid.ir/paper/30717/en

    Vancouver: Copy

    MOUKHAH SOMAYEH, GOSHTASEBI AZITA, MOAYED MOHSENI SAKINEH. CLINICAL TRIAL OF MEDROXYPROGESTRONE ACETATE ON MENSTUREAL BLOOD LOSS AND QUALITYOF LIFE IN WOMEN WITH MENORRHAGIA. DANESHVAR MEDICINE[Internet]. 2011;18(93):21-32. Available from: https://sid.ir/paper/30717/en

    IEEE: Copy

    SOMAYEH MOUKHAH, AZITA GOSHTASEBI, and SAKINEH MOAYED MOHSENI, “CLINICAL TRIAL OF MEDROXYPROGESTRONE ACETATE ON MENSTUREAL BLOOD LOSS AND QUALITYOF LIFE IN WOMEN WITH MENORRHAGIA,” DANESHVAR MEDICINE, vol. 18, no. 93, pp. 21–32, 2011, [Online]. Available: https://sid.ir/paper/30717/en

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