COMPARING THE IMPACT OF HORMONE REPLACEMENT THERAPY WITH THREE REGIMENS (CONJUGATED ESTROGEN ALONE AND WITH 2.5 OR 3 MG MEDROXY PROGESTERONE ACETATE) ON LIPID PROFILE, FASTING BLOOD SUGAR AND GLUCOSE TOLERANCE AND BODY WEIGHT OF POSTMENOPAUSAL WOMEN

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AKBARI ASBAGH F.; MAHMOUDAN A.

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Paper Information

Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2005 | Volume:63 | Issue:9 Page(s): 742-750

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Title

COMPARING THE IMPACT OF HORMONE REPLACEMENT THERAPY WITH THREE REGIMENS (CONJUGATED ESTROGEN ALONE AND WITH 2.5 OR 3 MG MEDROXY PROGESTERONE ACETATE) ON LIPID PROFILE, FASTING BLOOD SUGAR AND GLUCOSE TOLERANCE AND BODY WEIGHT OF POSTMENOPAUSAL WOMEN

Author(s)

AKBARI ASBAGH F. | MAHMOUDAN A. | Issue Writer Certificate

Keywords

HORMONE REPLACEMENT THERAPY AND LIPID PROFILEQ4

AND TGQ4

AND FBSQ4

AND OGTT AND BODY WEIGHTQ4

Abstract

Background: To evaluate the impact of HRT wit three regimens (conjugated estrogen alone & with 2.5mg or 5mg MPA) on lipid profile, FBS, OGTT & body weight of postmenopausal women. Methods and Materials: In this prospective randomized clinical trial, 70 menopause women who had come to "Mirza Koochak-Khan Hospital" (Tehran University) for receiving HRT in 2 years (1381-1382) entered randomly in 3 groups of study. All participants received 0.625 mg conjugated estrogen daily. One group received 2.5 mg MPA and another received 5 mg MPA too, continuously for 6 months. FBS, TG, Cholesterol, HDL and LDL measurement was done before starting HRT and after *1), (3) and (6) months of therapy. OGTT was performed before study and after 3 and 6 months. Results: There were no significant difference between groups before treatment. Although beneficial effects on cholesterol, LDL and HDL occurred in all groups, but were greatest with conjugated estrogen alone (p< 0.05) (with 6 months change of: total cholesterol: -21.2 mg/dl, HDL: +9.16 mg/dl, LDL: -21.87 mg/dl). TG levels elevated significantly in this group (+34.41 mg/dl) (p< 0.05). In 2.5 mg MPA group, beneficial effects on lipid profile were slightly attenuated AND TG level elevated less significantly. In 5 mg MPA group, beneficial effects of estrogen on cholesterol, LDL and HDL had greater attenuation and there was no overall change in TG level. FBS level decreased in estrogen group (-8.16 mg/dl in 6 months, P< 0.05), there was less beneficial effect on 2.5 mg MPA group and negative effect on 5 mg MPA group (+5.4 mg/dl in 6 months, P< 0.05). Similar effects were occurred in OGTT levels. Body weight increased in all groups, with more significant change in 2.5 mg MPA group (+2.56 kg, P< 0.05) and the least change in 5 mg MPA group (0.22 kg, P> 0.05).Conclusions: By adding 2.5 mg MPA to conjugated estrogen, mild attenuation in beneficial effects of estrogen on lipid profile, FBS and OGTT occurred and adverse effect of estrogen on TG level decreased. By increasing MPA dosage to 5 mg, greater attenuation in beneficial effects on FBS and OGTT occurred and adverse effect of estrogen on TG completely reversed.

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APA: Copy

AKBARI ASBAGH, F., & MAHMOUDAN, A.. (2005). COMPARING THE IMPACT OF HORMONE REPLACEMENT THERAPY WITH THREE REGIMENS (CONJUGATED ESTROGEN ALONE AND WITH 2.5 OR 3 MG MEDROXY PROGESTERONE ACETATE) ON LIPID PROFILE, FASTING BLOOD SUGAR AND GLUCOSE TOLERANCE AND BODY WEIGHT OF POSTMENOPAUSAL WOMEN. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 63(9), 742-750. SID. https://sid.ir/paper/38688/en

Vancouver: Copy

AKBARI ASBAGH F., MAHMOUDAN A.. COMPARING THE IMPACT OF HORMONE REPLACEMENT THERAPY WITH THREE REGIMENS (CONJUGATED ESTROGEN ALONE AND WITH 2.5 OR 3 MG MEDROXY PROGESTERONE ACETATE) ON LIPID PROFILE, FASTING BLOOD SUGAR AND GLUCOSE TOLERANCE AND BODY WEIGHT OF POSTMENOPAUSAL WOMEN. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2005;63(9):742-750. Available from: https://sid.ir/paper/38688/en

IEEE: Copy

F. AKBARI ASBAGH, and A. MAHMOUDAN, “COMPARING THE IMPACT OF HORMONE REPLACEMENT THERAPY WITH THREE REGIMENS (CONJUGATED ESTROGEN ALONE AND WITH 2.5 OR 3 MG MEDROXY PROGESTERONE ACETATE) ON LIPID PROFILE, FASTING BLOOD SUGAR AND GLUCOSE TOLERANCE AND BODY WEIGHT OF POSTMENOPAUSAL WOMEN,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 63, no. 9, pp. 742–750, 2005, [Online]. Available: https://sid.ir/paper/38688/en

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