THE EFFECT OF SIMULTANEOUS INHIBITION OF ENZYMES WHICH PRODUCE NITRIC OXIDE AND PROSTAGLANDINS IN MODULATION OF VASCULAR ALPHA-1 ADRENOCEPTORS RESPONSIVENESS TO PHENYLEPHRINE IN CHRONICALLY INFLAMED RAT KNEE JOINT

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PEZHHAN A.; HAJIZADEH S.; KHOUSHBATEN A.; FATH ELAHI Y.

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Journal Paper

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Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2005 | Volume:12 | Issue:57 Page(s): 9-20

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Title

THE EFFECT OF SIMULTANEOUS INHIBITION OF ENZYMES WHICH PRODUCE NITRIC OXIDE AND PROSTAGLANDINS IN MODULATION OF VASCULAR ALPHA-1 ADRENOCEPTORS RESPONSIVENESS TO PHENYLEPHRINE IN CHRONICALLY INFLAMED RAT KNEE JOINT

Author(s)

PEZHHAN A. | HAJIZADEH S. | KHOUSHBATEN A. | FATH ELAHI Y. | Issue Writer Certificate

Keywords

NITRIC OXIDEQ2

PROSTAGLANDINQ3

KNEE JOINTQ3

CHRONIC INFLAMMATIONQ4

ALPHA-1 ADRENOCEPTORQ4

BLOOD FLOWQ4

Abstract

Introduction: The effect of simultaneous inhibition of production of NITRIC OXIDE and PROSTAGLANDIN was investigated on modulation of vascular alpha.- 1 adrenoceptors responsiveness to phenylephrine in chronically inflamed rat KNEE JOINT. Method: Joint inflammation was induced by unilateral intraarticular injection of Freund's Complete Adjuvant (FCA) into right KNEE JOINT and experiments were done on the ipsilateral (right) and contra lateral (left) joints for 28 days. BLOOD FLOW measurements of the exposed joints were obtained using a Laser Doppler Flow meter (LDF). Results: Injection of FCA caused a significant increase in the diameter of both ipsilateral and contra lateral knee as compared with preinjection diameter. Topical application of phenylephrine (10-11 to 10-7 molar) in normal rats produced a dose-dependent vasoconstriction of the articular microvasculature. This constricted response was decreased in contra lateral KNEE JOINT of inflamed animals for 14 days, but had no significant effect on ipsilateral knee. After simultaneous treatment with Aminoguanidine (120 mg/kg i.p daily) and indomethacin (3 mg/kg i.p. daily) on the third and 14th day of FCA injection, vasoconstrictor responses to phenylephrine increased and returned to control value in contra lateral knee but not in ipsilateral knee. Conclusion: These data suggest that NITRIC OXIDE and PROSTAGLANDINs seem to be involved in modulation of vasoconstrictor response of vascular ALPHA-1 ADRENOCEPTORs to phenylephrine.

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APA: Copy

PEZHHAN, A., HAJIZADEH, S., KHOUSHBATEN, A., & FATH ELAHI, Y.. (2005). THE EFFECT OF SIMULTANEOUS INHIBITION OF ENZYMES WHICH PRODUCE NITRIC OXIDE AND PROSTAGLANDINS IN MODULATION OF VASCULAR ALPHA-1 ADRENOCEPTORS RESPONSIVENESS TO PHENYLEPHRINE IN CHRONICALLY INFLAMED RAT KNEE JOINT. DANESHVAR MEDICINE, 12(57), 9-20. SID. https://sid.ir/paper/30733/en

Vancouver: Copy

PEZHHAN A., HAJIZADEH S., KHOUSHBATEN A., FATH ELAHI Y.. THE EFFECT OF SIMULTANEOUS INHIBITION OF ENZYMES WHICH PRODUCE NITRIC OXIDE AND PROSTAGLANDINS IN MODULATION OF VASCULAR ALPHA-1 ADRENOCEPTORS RESPONSIVENESS TO PHENYLEPHRINE IN CHRONICALLY INFLAMED RAT KNEE JOINT. DANESHVAR MEDICINE[Internet]. 2005;12(57):9-20. Available from: https://sid.ir/paper/30733/en

IEEE: Copy

A. PEZHHAN, S. HAJIZADEH, A. KHOUSHBATEN, and Y. FATH ELAHI, “THE EFFECT OF SIMULTANEOUS INHIBITION OF ENZYMES WHICH PRODUCE NITRIC OXIDE AND PROSTAGLANDINS IN MODULATION OF VASCULAR ALPHA-1 ADRENOCEPTORS RESPONSIVENESS TO PHENYLEPHRINE IN CHRONICALLY INFLAMED RAT KNEE JOINT,” DANESHVAR MEDICINE, vol. 12, no. 57, pp. 9–20, 2005, [Online]. Available: https://sid.ir/paper/30733/en

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