Methylation of IFN-γ in sulfur mustardexposed patients

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Vafa Ashraf; FAGHIHZADEH SOGHRAT; Ghafarpour Sarah; Behboodi Hossein; Zamani Mohammad Saber; GHAZANFARI TOOBA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2019 | Volume:27 | Issue:144 Page(s): 17-24

Download Full-Text

Persian Verion

View:

502

Download:

Cites:

Information Journal Paper

Title

Methylation of IFN-γ in sulfur mustardexposed patients

Author(s)

Keywords

MethylationQ2

IFN-γQ1

Sulfur mustardQ1

Pulmonary complicationsQ2

Abstract

Introduction: IFN-γ is one of the most important cytokines in the development of chronic inflammatory diseases such as asthma and COPD. The IFN-γ promoter Methylation at CpG islands could be altered by various chemical and toxic substances which may have a role in the incidence of chronic pulmonary diseases and its severity. Thereby, the present study was aimed to evaluate the effect of Sulfur mustard gas on the Methylation status of IFN-γ gene promoter and its correlation with the severity of pulmonary disease in chemical veterans with delayed Pulmonary complications. Methods: 46 Sulfur mustard-exposed individuals with mild-moderate Pulmonary complications, 45 with severe Pulmonary complicationsand 41 unexposed individuals as a control group participated. The quality and quantity of extracted DNA were assessed by the nanodrop machine. After treatment with bisulfite, the Methylation of IFN-γ gene promoter was evaluated by Methylationspecific PCR. Results: The Methylation of IFN-γ gene promoter showed a significant increase in exposed-patients with mild to moderate Pulmonary complications and a significant reduction in exposed-patients with severe Pulmonary complications compared to the control groups. The levels of spirometric parameters were significantly higher in individuals with Methylated DNA compared with those with unmethylated DNA. Conclusion: It could be suggested that hyper-Methylation of IFN-γ gene promoter and probable changes in IFN-γ gene expressionhave a positive effect on lung function in SM-exposed individuals.

Cites

No record.

References

No record.

Cite

APA: Copy

Vafa, Ashraf, FAGHIHZADEH, SOGHRAT, Ghafarpour, Sarah, Behboodi, Hossein, Zamani, Mohammad Saber, & GHAZANFARI, TOOBA. (2019). Methylation of IFN-γ in sulfur mustardexposed patients. DANESHVAR MEDICINE, 27(144 ), 17-24. SID. https://sid.ir/paper/30843/en

Vancouver: Copy

Vafa Ashraf, FAGHIHZADEH SOGHRAT, Ghafarpour Sarah, Behboodi Hossein, Zamani Mohammad Saber, GHAZANFARI TOOBA. Methylation of IFN-γ in sulfur mustardexposed patients. DANESHVAR MEDICINE[Internet]. 2019;27(144 ):17-24. Available from: https://sid.ir/paper/30843/en

IEEE: Copy

Ashraf Vafa, SOGHRAT FAGHIHZADEH, Sarah Ghafarpour, Hossein Behboodi, Mohammad Saber Zamani, and TOOBA GHAZANFARI, “Methylation of IFN-γ in sulfur mustardexposed patients,” DANESHVAR MEDICINE, vol. 27, no. 144 , pp. 17–24, 2019, [Online]. Available: https://sid.ir/paper/30843/en

Related Journal Papers