A COMPARISON OF SPOT URINE PROTEIN-CREATININE RATIO WITH 24-HOUR URINE PROTEIN EXCRETION IN WOMEN WITH PREECLAMPSIA

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SHAHBAZIAN N.; HOSSEINI ASL F.

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Paper Information

Journal: Iranian Journal of Kidney Diseases Year:2008 | Volume:2 | Issue:3 Page(s): 127-131

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Title

A COMPARISON OF SPOT URINE PROTEIN-CREATININE RATIO WITH 24-HOUR URINE PROTEIN EXCRETION IN WOMEN WITH PREECLAMPSIA

Author(s)

SHAHBAZIAN N. | HOSSEINI ASL F. | Issue Writer Certificate

Keywords

PREGNANCY

PROTEINURIA

CREATININE

PREECLAMPSIA

Abstract

Introduction: PROTEINURIA is an important diagnostic component of PREECLAMPSIA. We prospectively compared the results of spot urine protein-creatinine (P/C) ratio with 24-hour urine protein excretion in women with PREECLAMPSIA. Materials and Methods: A total of 81 pregnant women with PREECLAMPSIA were prospectively studied for PROTEINURIA. Urine P/C ratio was determined in a spot mid-stream urine sample, and the amount of protein excretion was measured in 24-hour urine collected on the subsequent day. The correlation between the spot P/C ratio and 24-hour urine protein excretion was assessed. Diagnostic value of P/C ratio was expressed in terms of specificity and sensitivity. The receiver operating characteristic curve analysis was used to determine the best discriminator values of the spot urine P/C ratios for PREECLAMPSIA (proteinuria³300 mg/24 h). Results: There was a strong correlation between the spot P/C ratio and 24-hour urine protein excretion (r=0.84; P<.001). The optimal spot P/C ratio cutoff point was 0.20 for 300 mg/24 h of protein excretion (preeclampsia), with a sensitivity, specificity, positive predictive value, and negative predictive value of 91.2%, 87.8%, 94.4%, and 96.8%, respectively. The spot P/C ratios less than 0.19 yielded a sensitivity of 100% for exclusion of PREECLAMPSIA. Conclusions: We found that there is a significant correlation between the spot urine P/C ratio and 24-hour urine protein excretion in women with PREECLAMPSIA. Urine P/C ratio could be used for exclusion of PREECLAMPSIA.

Cites

THE COMPARISON OF QUANTITATIVE 8 AND 24 HOUR URINE PROTEIN SAMPLES FOR DIAGNOSIS OF PREECLAMPSIA

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APA: Copy

SHAHBAZIAN, N., & HOSSEINI ASL, F.. (2008). A COMPARISON OF SPOT URINE PROTEIN-CREATININE RATIO WITH 24-HOUR URINE PROTEIN EXCRETION IN WOMEN WITH PREECLAMPSIA. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 2(3), 127-131. SID. https://sid.ir/paper/308645/en

Vancouver: Copy

SHAHBAZIAN N., HOSSEINI ASL F.. A COMPARISON OF SPOT URINE PROTEIN-CREATININE RATIO WITH 24-HOUR URINE PROTEIN EXCRETION IN WOMEN WITH PREECLAMPSIA. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2008;2(3):127-131. Available from: https://sid.ir/paper/308645/en

IEEE: Copy

N. SHAHBAZIAN, and F. HOSSEINI ASL, “A COMPARISON OF SPOT URINE PROTEIN-CREATININE RATIO WITH 24-HOUR URINE PROTEIN EXCRETION IN WOMEN WITH PREECLAMPSIA,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 2, no. 3, pp. 127–131, 2008, [Online]. Available: https://sid.ir/paper/308645/en

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