LOW-DOSE DOXEPIN FOR TREATMENT OF PRURITUS IN PATIENTS ON HEMODIALYSIS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

POURREZA GHOLI F.; NASR ELAHI A.R.; FIROUZAN A.; NASLI ESFAHANI E.; FAROKHI FARHAT

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Kidney Diseases Year:2007 | Volume:1 | Issue:1 Page(s): 34-37

Download Full-Text

View:

419

Download:

433

Cites:

Information Journal Paper

Title

LOW-DOSE DOXEPIN FOR TREATMENT OF PRURITUS IN PATIENTS ON HEMODIALYSIS

Author(s)

Keywords

PRURITUS

DOXEPIN

END-STAGE RENAL DISEASE

DIALYSIS

Abstract

Introduction: PRURITUS is one of the frequent discomforting complications in patients with END-STAGE RENAL DISEASE. We prospectively evaluated the effectiveness of DOXEPIN, an H1-receptor antagonist of histamine, in patients with PRURITUS resistant to conventional treatment. Materials and Methods: A randomized controlled trial with a crossover design was performed on 24 patients in whom other etiologic factors of PRURITUS had been ruled out. They were assigned into 2 groups and received either placebo or oral DOXEPIN, 10 mg, twice a day for 1 week. After a 1-week washout period, the 2 groups were treated conversely. Subjective outcome was determined by asking the patients described their PRURITUS as completely improved, relatively improved, or remained unchanged/worsened. Results: Complete resolution of PRURITUS was reported in 14 patients (58.3%) with DOXEPIN and 2 (8.3%) with placebo (P<.001). Relative improvement was observed in 7 (29.2%) and 4 (16.7%), respectively. Overall, the improving effect of DOXEPIN on PRURITUS was seen in 87.5% of the patients. Twelve patients (50.0%) complained of drowsiness that alleviated in all cases after 2 days in average. One patient refused to continue the treatment due to its sedative effect. Conclusions: We suggest that DOXEPIN, a tricyclic antidepressant with anti-H1 receptor effect, can help improve PRURITUS resistant to antihistamines in END-STAGE RENAL DISEASE patients who undergo hemodialysis. A low dose of DOXEPIN is safe while effective and its main adverse effect, drowsiness, is temporary and can be easily tolerated by the patients.

Cites

No record.

References

No record.

Cite

APA: Copy

POURREZA GHOLI, F., NASR ELAHI, A.R., FIROUZAN, A., NASLI ESFAHANI, E., & FAROKHI, FARHAT. (2007). LOW-DOSE DOXEPIN FOR TREATMENT OF PRURITUS IN PATIENTS ON HEMODIALYSIS. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 1(1), 34-37. SID. https://sid.ir/paper/308699/en

Vancouver: Copy

POURREZA GHOLI F., NASR ELAHI A.R., FIROUZAN A., NASLI ESFAHANI E., FAROKHI FARHAT. LOW-DOSE DOXEPIN FOR TREATMENT OF PRURITUS IN PATIENTS ON HEMODIALYSIS. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2007;1(1):34-37. Available from: https://sid.ir/paper/308699/en

IEEE: Copy

F. POURREZA GHOLI, A.R. NASR ELAHI, A. FIROUZAN, E. NASLI ESFAHANI, and FARHAT FAROKHI, “LOW-DOSE DOXEPIN FOR TREATMENT OF PRURITUS IN PATIENTS ON HEMODIALYSIS,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 1, no. 1, pp. 34–37, 2007, [Online]. Available: https://sid.ir/paper/308699/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops