Evaluation of niosomal nano-carriers capabilities on toxicity preservation and delivery of pomegranate peel extract in cell culture conditions (MCF-7 cell line of breast cancer)

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Askari Maliha; NIKOONAHAD LOTFABADI NARGES

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Paper Information

Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2018 | Volume:26 | Issue:138 Page(s): 9-20

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Title

Evaluation of niosomal nano-carriers capabilities on toxicity preservation and delivery of pomegranate peel extract in cell culture conditions (MCF-7 cell line of breast cancer)

Author(s)

Askari Maliha | NIKOONAHAD LOTFABADI NARGES | Issue Writer Certificate

Keywords

Medicinal plantsQ2

Pomegranate peelQ1

NiosomeQ1

Nano-carrierQ1

MCF-7 cell lineQ2

Abstract

Background and Objective: Use of Nano-carriers that contain plant cytotoxic compounds instead of common chemotherapy drugs can reduce many of the challenges in front of this method of cancer therapy. In this study, surfactant nano-systems containing Pomegranate peel extract were designed to evaluate its cytotoxic effects on MCF-7 cell line (breast cancer) and investigated its physicochemical properties. Materials and Methods: Niosomal vesicles were prepared using span60, cholesterol and polyethylene glycol by thin-film method and the Pomegranate peel extract were loaded into the Niosomes. Physicochemical characteristics were evaluated using Zeta Sizer, FTIR, SEM, and extract release amount was calculated at 37° C and 42° C. The toxicity of the Nano-carrier containing extract was measured on the MCF-7 cell line of breast cancer using MTT assay. Results: The results of this study indicate that the Niosomes-containing extract has the encapsulation efficiency, size, and surface charge as 61. 28%, 14. 36 nm, and 40. 9 mV, respectively. The study of its releasing also shows that the niosomal Nano-carrier has controlled release at 37° C and 42° C. The study of FTIR confirms that there is no interaction between peel extract and Nano-carrier. Also, SEM shows the spherical morphology of the Nano-carriers. MTT results demonstrate that the toxic effects of Niosomes-contained Pomegranate peel extract on MCF-7 cell line of breast cancer is higher than peel extract alone. Conclusion: According to the results of this investigation, it is indicated that the carrier niosomal nano vesicles can be a suitable carrier for delivery of Pomegranate peel extract in conditions of cancerous cells.

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APA: Copy

Askari, Maliha, & NIKOONAHAD LOTFABADI, NARGES. (2018). Evaluation of niosomal nano-carriers capabilities on toxicity preservation and delivery of pomegranate peel extract in cell culture conditions (MCF-7 cell line of breast cancer). DANESHVAR MEDICINE, 26(138 ), 9-20. SID. https://sid.ir/paper/30871/en

Vancouver: Copy

Askari Maliha, NIKOONAHAD LOTFABADI NARGES. Evaluation of niosomal nano-carriers capabilities on toxicity preservation and delivery of pomegranate peel extract in cell culture conditions (MCF-7 cell line of breast cancer). DANESHVAR MEDICINE[Internet]. 2018;26(138 ):9-20. Available from: https://sid.ir/paper/30871/en

IEEE: Copy

Maliha Askari, and NARGES NIKOONAHAD LOTFABADI, “Evaluation of niosomal nano-carriers capabilities on toxicity preservation and delivery of pomegranate peel extract in cell culture conditions (MCF-7 cell line of breast cancer),” DANESHVAR MEDICINE, vol. 26, no. 138 , pp. 9–20, 2018, [Online]. Available: https://sid.ir/paper/30871/en

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