Designing and Characterizing Nano-carriers Containing Nepeta Persica Extract and Their Effect on Bone Cancer

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Aboeepoor Samanah; DEHGHANI ASHKEZARI MAHMOOD; Aboee Mehrizi Fateme; HAGHIRALSADAT BIBI FATEMEH; NIKOONAHAD LOTFABADI NARGES

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Journal: Internal Medicine Today Year:2020 | Volume:26 | Issue:2 Page(s): 142-155

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Title

Designing and Characterizing Nano-carriers Containing Nepeta Persica Extract and Their Effect on Bone Cancer

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Keywords

Nepta persicaQ1

NoisomeQ1

MTTQ2

MG63 Cell lineQ1

Abstract

Aims Niosomes have been considered as carriers for targeted delivery of drugs in modern drug delivery systems. The Iranian Nepta (Nepta genus) has unique biological properties; thus, this plant was used in this study to prepare the optimized formulation of niosomes containing extract, and to evaluate its cytotoxicity. Methods & Materials Initially, the extract of Iranian Nepta (N. persica) was prepared. Then, the nanoniosomal system, containing the extract was designed and synthesized using cholesterol and Span-60. The physicochemical properties of the system were evaluated by FTIR and SEM. MTT assay [3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide] was used to determine the toxicity of the Nepta extract and nano-system containing it against bone cancer cells (MG63). Findings An optimized formulation was obtained using cholesterol and Span-60 with a ratio of 80: 20. The amount of extract release from this formulation continued with a steady slope over a long period of time. The survival rate of MG63 cells against 100 μ g/mL of the free form of N. persica extract and its niosomal form were 22% and 8. 88%, respectively. Conclusion The present research results suggested that N. persica extract exert anti-cancer effects and niosome could improve its anti-cancer efficiency. Therefore, it could be used as a proper carrier to deliver the extract to the target tissue.

Cites

طراحی، ساخت و مشخصه یابی نانو حامل های نیوزومی حاوی داروی پاکلی تاکسل جهت دارورسانی به رده سلولی استئوسارکوما (Saos-2)

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APA: Copy

Aboeepoor, Samanah, DEHGHANI ASHKEZARI, MAHMOOD, Aboee Mehrizi, Fateme, HAGHIRALSADAT, BIBI FATEMEH, & NIKOONAHAD LOTFABADI, NARGES. (2020). Designing and Characterizing Nano-carriers Containing Nepeta Persica Extract and Their Effect on Bone Cancer. OFOGH-E-DANESH, 26(2 ), 142-155. SID. https://sid.ir/paper/372218/en

Vancouver: Copy

Aboeepoor Samanah, DEHGHANI ASHKEZARI MAHMOOD, Aboee Mehrizi Fateme, HAGHIRALSADAT BIBI FATEMEH, NIKOONAHAD LOTFABADI NARGES. Designing and Characterizing Nano-carriers Containing Nepeta Persica Extract and Their Effect on Bone Cancer. OFOGH-E-DANESH[Internet]. 2020;26(2 ):142-155. Available from: https://sid.ir/paper/372218/en

IEEE: Copy

Samanah Aboeepoor, MAHMOOD DEHGHANI ASHKEZARI, Fateme Aboee Mehrizi, BIBI FATEMEH HAGHIRALSADAT, and NARGES NIKOONAHAD LOTFABADI, “Designing and Characterizing Nano-carriers Containing Nepeta Persica Extract and Their Effect on Bone Cancer,” OFOGH-E-DANESH, vol. 26, no. 2 , pp. 142–155, 2020, [Online]. Available: https://sid.ir/paper/372218/en

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