HIGH FREQUENCY OF CLINICALLY SIGNIFICANT INFECTIONS AND CYTOMEGALOVIRUS DISEASE IN KIDNEY TRANSPLANT RECIPIENTS WITH SERUM MANNOSE-BINDING LECTIN DEFICIENCY

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GHODS F.J.; SOLGI GH.; AMIRZARGAR ALI AKBAR; NIKBIN B.; GHODS A.J.

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Journal: Iranian Journal of Kidney Diseases Year:2009 | Volume:3 | Issue:1 Page(s): 28-33

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Title

HIGH FREQUENCY OF CLINICALLY SIGNIFICANT INFECTIONS AND CYTOMEGALOVIRUS DISEASE IN KIDNEY TRANSPLANT RECIPIENTS WITH SERUM MANNOSE-BINDING LECTIN DEFICIENCY

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Keywords

MANNOSE-BINDING LECTIN

CYTOMEGALOVIRUS

INFECTIONS

KIDNEY TRANSPLANTATION

Abstract

Introduction: MANNOSE-BINDING LECTIN (MBL) constitutes defense against INFECTIONS when adaptive immune response is compromised. Elevation in serum MBL levels has been shown in patients with kidney failure. We compared serum MBL levels before and after kidney transplant and evaluated association of MBL deficiency with infectious complications in kidney transplant recipients.Materials and Methods: This study was performed in 71 kidney transplant recipients and 48 healthy controls. In 36 recipients (group 1), serum MBL levels were tested before and on days 7 and 14 after transplantation. They were followed up for 6 months. In 35 recipients (group 2), serum MBL was measured during their posttransplant follow-up visits. In both groups, frequencies of clinically significant INFECTIONS and acute rejection were compared between those with low MBL (<500ng/mL) and normal/highResults: Serum MBL levels (1744 ± 905ng/mL) were not higher in group 1 before transplantation than in controls. One and 2 weeks after transplantation, MBL levels decreased to 1699±1030ngmL and 1562±1020ng/mL, respectively. Five patients who had low serum MBL levels experienced more frequent episodes of INFECTIONS (P=.008) and CMV disease (P<.001). Ten patients in group 2 with low MBL levels had more frequent episodes of CMV disease (P=.01).Conclusions: These findings suggest a potential role for MBL in defense against developing posttransplant CMV disease and that low serum MBL levels in kidney transplant recipients be considered an indicator of the need for CMV prophylaxis.

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APA: Copy

GHODS, F.J., SOLGI, GH., AMIRZARGAR, ALI AKBAR, NIKBIN, B., & GHODS, A.J.. (2009). HIGH FREQUENCY OF CLINICALLY SIGNIFICANT INFECTIONS AND CYTOMEGALOVIRUS DISEASE IN KIDNEY TRANSPLANT RECIPIENTS WITH SERUM MANNOSE-BINDING LECTIN DEFICIENCY. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 3(1), 28-33. SID. https://sid.ir/paper/308723/en

Vancouver: Copy

GHODS F.J., SOLGI GH., AMIRZARGAR ALI AKBAR, NIKBIN B., GHODS A.J.. HIGH FREQUENCY OF CLINICALLY SIGNIFICANT INFECTIONS AND CYTOMEGALOVIRUS DISEASE IN KIDNEY TRANSPLANT RECIPIENTS WITH SERUM MANNOSE-BINDING LECTIN DEFICIENCY. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2009;3(1):28-33. Available from: https://sid.ir/paper/308723/en

IEEE: Copy

F.J. GHODS, GH. SOLGI, ALI AKBAR AMIRZARGAR, B. NIKBIN, and A.J. GHODS, “HIGH FREQUENCY OF CLINICALLY SIGNIFICANT INFECTIONS AND CYTOMEGALOVIRUS DISEASE IN KIDNEY TRANSPLANT RECIPIENTS WITH SERUM MANNOSE-BINDING LECTIN DEFICIENCY,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 3, no. 1, pp. 28–33, 2009, [Online]. Available: https://sid.ir/paper/308723/en

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