ANGIOTENSIN-CONVERTING ENZYME INSERTION/DELETION GENE POLYMORPHISM IN GENERAL POPULATION OF WEST AZARBAIJAN, IRAN

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ABDI RAD ISA; BAGHERI MORTEZA

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Journal: Iranian Journal of Kidney Diseases Year:2011 | Volume:5 | Issue:2 Page(s): 86-92

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Title

ANGIOTENSIN-CONVERTING ENZYME INSERTION/DELETION GENE POLYMORPHISM IN GENERAL POPULATION OF WEST AZARBAIJAN, IRAN

Author(s)

ABDI RAD ISA | BAGHERI MORTEZA | Issue Writer Certificate

Keywords

ANGIOTENSINCONVERTING ENZYME

GENETIC POLYMORPHISM

GENE FREQUENCY

ALLELES

IRAN

Abstract

Introduction. Angiotensin-converting enzyme (ACE) gene polymorphisms have been studied in different ethnic populations.We assessed the ACE gene insertion/deletion ALLELES frequencies and genotype distributions in a group of individuals from among the general population of west Azarbaijan, IRAN, in order to determine the prevalence of deletion/deletion (D/D), deletion/insertion (D/I) and insertion/insertion (I/I) genotypes.Materials and Methods. In a cross-sectional study, 167 healthy individuals were enrolled in a randomized fashion. They were selected from the general population of west Azerbaijan, IRAN.Polymerase chain reaction was carried out to determine the ACE D/D, D/I and I/I genotypes.Results. The ACE ALLELES were D and I in 59.7% and 40.3% of the women, 59.3% and 40.7% of the men and 59.6% and 40.4% of all of the participants, respectively. The D/D, D/I, and I/I genotypes were observed in 22 (40.7%), 20 (37%), and 12 (22.2%) men, 41 (36.3%), 53 (46.9%), and 19 (16.8%) women, and 63 (37.7%), 73 (43.7%), and 31 (18.6%) participants, respectively. Statistical analysis showed that differences in ACE D and I ALLELES and genotype frequencies were not significant between the men and the women.Conclusions. In this study on the general population of west Azarbaijan, the frequencies of the ACE D and I ALLELES were 59.6% and 40.4%. The ACE D/D, D/I and I/I genotypes were seen in 37.7%, 43.7%, and 18.6% of the studied population, respectively.

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APA: Copy

ABDI RAD, ISA, & BAGHERI, MORTEZA. (2011). ANGIOTENSIN-CONVERTING ENZYME INSERTION/DELETION GENE POLYMORPHISM IN GENERAL POPULATION OF WEST AZARBAIJAN, IRAN. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 5(2), 86-92. SID. https://sid.ir/paper/309051/en

Vancouver: Copy

ABDI RAD ISA, BAGHERI MORTEZA. ANGIOTENSIN-CONVERTING ENZYME INSERTION/DELETION GENE POLYMORPHISM IN GENERAL POPULATION OF WEST AZARBAIJAN, IRAN. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2011;5(2):86-92. Available from: https://sid.ir/paper/309051/en

IEEE: Copy

ISA ABDI RAD, and MORTEZA BAGHERI, “ANGIOTENSIN-CONVERTING ENZYME INSERTION/DELETION GENE POLYMORPHISM IN GENERAL POPULATION OF WEST AZARBAIJAN, IRAN,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 5, no. 2, pp. 86–92, 2011, [Online]. Available: https://sid.ir/paper/309051/en

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