GENE POLYMORPHISM OF COMPLEMENT FACTOR H IN A TURKISH PATIENT WITH MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS TYPE II

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SOZERI BETUL; MIR SEVGI; BERDELI AFIG; DINCEL NIDA; SARSIK BANU

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Kidney Diseases Year:2012 | Volume:6 | Issue:2 Page(s): 149-153

Download Full-Text

View:

278

Download:

175

Cites:

Information Journal Paper

Title

GENE POLYMORPHISM OF COMPLEMENT FACTOR H IN A TURKISH PATIENT WITH MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS TYPE II

Author(s)

Keywords

MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS

COMPLEMENT FACTOR H

GENETIC POLYMORPHISM

Abstract

MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS (MPGN) is characterized by proliferation of mesangial and endothelial cells and by thickening of the peripheral capillary walls. Type II of the MPGN is associated with complement abnormalities which are factor H deficiencies due to mutations in the COMPLEMENT FACTOR H (CFH) gene. We report a 15-year-old boy diagnosed with MPGN II in whom genetic analyses of the CFH gene revealed that the patient was heterozygote for a polymorphism in exon 2 of the CFH (c.184G>A), heterozygote for a polymorphism in exon 9 of the CFH (c.1204C>T), and heterozygote for a polymorphism in exon 10 of the CFH (c.1419G>A). These data recapitulate a prototypical complement genetic profile, the presence of major risk factors for MPGN II, which support the hypothesis that these dense deposit diseases have a common pathogenic mechanism involving dysregulation of the alternative pathway of complement activation.

Cites

No record.

References

No record.

Cite

APA: Copy

SOZERI, BETUL, MIR, SEVGI, BERDELI, AFIG, DINCEL, NIDA, & SARSIK, BANU. (2012). GENE POLYMORPHISM OF COMPLEMENT FACTOR H IN A TURKISH PATIENT WITH MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS TYPE II. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 6(2), 149-153. SID. https://sid.ir/paper/309184/en

Vancouver: Copy

SOZERI BETUL, MIR SEVGI, BERDELI AFIG, DINCEL NIDA, SARSIK BANU. GENE POLYMORPHISM OF COMPLEMENT FACTOR H IN A TURKISH PATIENT WITH MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS TYPE II. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2012;6(2):149-153. Available from: https://sid.ir/paper/309184/en

IEEE: Copy

BETUL SOZERI, SEVGI MIR, AFIG BERDELI, NIDA DINCEL, and BANU SARSIK, “GENE POLYMORPHISM OF COMPLEMENT FACTOR H IN A TURKISH PATIENT WITH MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS TYPE II,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 6, no. 2, pp. 149–153, 2012, [Online]. Available: https://sid.ir/paper/309184/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops