مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

INVERSE ASSOCIATION OF SERUM 25-HYDROXYVITAMIN D WITH MARKERS OF INFLAMMATION AND SUPPRESSION OF OSTEOCLASTIC ACTIVITY IN HEMODIALYSIS PATIENTS

Pages

  129-135

Abstract

 Introduction: In HEMODIALYSIS patients, 25-hydroxyvitamin D conversion to active 1, 25-dihydroxyvitamin D by the kidneys is very limited. The expression of both VITAMIN D receptor and 1α-hydroxylase in cells of the immune system and in both osteoblasts and osteoclasts makes it possible that 25-hydroxyvitamin D could play an important role in both INFLAMMATION and BONE METABOLISM acting in a autocrine and/or paracrine way in these patients.Materials and Methods: Thirty-three HEMODIALYSIS patients not under VITAMIN D receptor agonist treatment were enrolled into the study. Serum levels of 25-hydroxyvitamin D, C-reactive protein (CRP), interleukin-6 (IL-6), receptor activator of nuclear factor- KB ligand (RANKL), and osteoprotegerin, as well as intact parathyroid hormone (PTH) were assessed by immunoassays.Results: Regarding INFLAMMATION, 25-hydroxyvitamin D inversely correlated with both CRP and IL-6. Regarding BONE METABOLISM, 25-hydroxyvitamin D was positively related to osteoprotegerin, but negatively to the RANKL. The latter could be the result of PTH suppression by 25-hydroxyvitamin D, since 25-hydroxyvitamin D negatively correlated with PTH, which in turn was positively related to RANKL.Conclusions: Serum 25-hydroxyvitamin D is inversely correlated with markers of INFLAMMATION and may suppress osteoclastic activity in HEMODIALYSIS patients.

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    APA: Copy

    ELEFTHERIADIS, THEODOROS, ANTONIADI, GEORGIA, LIAKOPOULOS, VASSILIOS, STEFANIDIS, IOANNIS, & GALAKTIDOU, GRAMMATI. (2012). INVERSE ASSOCIATION OF SERUM 25-HYDROXYVITAMIN D WITH MARKERS OF INFLAMMATION AND SUPPRESSION OF OSTEOCLASTIC ACTIVITY IN HEMODIALYSIS PATIENTS. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 6(2), 129-135. SID. https://sid.ir/paper/309189/en

    Vancouver: Copy

    ELEFTHERIADIS THEODOROS, ANTONIADI GEORGIA, LIAKOPOULOS VASSILIOS, STEFANIDIS IOANNIS, GALAKTIDOU GRAMMATI. INVERSE ASSOCIATION OF SERUM 25-HYDROXYVITAMIN D WITH MARKERS OF INFLAMMATION AND SUPPRESSION OF OSTEOCLASTIC ACTIVITY IN HEMODIALYSIS PATIENTS. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2012;6(2):129-135. Available from: https://sid.ir/paper/309189/en

    IEEE: Copy

    THEODOROS ELEFTHERIADIS, GEORGIA ANTONIADI, VASSILIOS LIAKOPOULOS, IOANNIS STEFANIDIS, and GRAMMATI GALAKTIDOU, “INVERSE ASSOCIATION OF SERUM 25-HYDROXYVITAMIN D WITH MARKERS OF INFLAMMATION AND SUPPRESSION OF OSTEOCLASTIC ACTIVITY IN HEMODIALYSIS PATIENTS,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 6, no. 2, pp. 129–135, 2012, [Online]. Available: https://sid.ir/paper/309189/en

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