CELLULAR AND MOLECULAR ASPECTS OF GOOD PASTURE SYNDROME

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ALENZI FARIS Q.; SALEM MOHAMED L.; ALENAZI FAWWAZ A.; WYSE RICHARD K.

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Journal Paper

Paper Information

Journal: Iranian Journal of Kidney Diseases Year:2012 | Volume:6 | Issue:1 Page(s): 1-8

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Title

CELLULAR AND MOLECULAR ASPECTS OF GOOD PASTURE SYNDROME

Author(s)

ALENZI FARIS Q. | SALEM MOHAMED L. | ALENAZI FAWWAZ A. | WYSE RICHARD K. | Issue Writer Certificate

Keywords

ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE

AUTOANTIBODIES

GLOMERULONEPHRITIS

MAJOR HISTOCOMPATIBILITY COMPLEX

Abstract

Good pasture syndrome, a rare human autoimmune disorder, is characterized by the presence of pathogenic AUTOANTIBODIES that react with the components of the glomerular basement membrane. The clinical condition of the Good pasture syndrome is characterized by an acute necrotizing GLOMERULONEPHRITIS, often with accompanying pulmonary hemorrhage. Notably, the Good pasture antigen has been localized to the noncollagenous domain of the a3 chain of type IV collagen. Additionally, human leukocyte antigen-DR2, and to a lesser extent human leukocyte antigen-DR4, have been identified as important restriction elements. The role of T cells in Good pasture syndrome is indicated by the highly restricted specificity of the antibody response and the strong MAJOR HISTOCOMPATIBILITY COMPLEX class II association. In this review article, we briefly describe the latest views on the molecular and cellular themes of Good pasture syndrome.

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APA: Copy

ALENZI, FARIS Q., SALEM, MOHAMED L., ALENAZI, FAWWAZ A., & WYSE, RICHARD K.. (2012). CELLULAR AND MOLECULAR ASPECTS OF GOOD PASTURE SYNDROME. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 6(1), 1-8. SID. https://sid.ir/paper/309317/en

Vancouver: Copy

ALENZI FARIS Q., SALEM MOHAMED L., ALENAZI FAWWAZ A., WYSE RICHARD K.. CELLULAR AND MOLECULAR ASPECTS OF GOOD PASTURE SYNDROME. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2012;6(1):1-8. Available from: https://sid.ir/paper/309317/en

IEEE: Copy

FARIS Q. ALENZI, MOHAMED L. SALEM, FAWWAZ A. ALENAZI, and RICHARD K. WYSE, “CELLULAR AND MOLECULAR ASPECTS OF GOOD PASTURE SYNDROME,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 6, no. 1, pp. 1–8, 2012, [Online]. Available: https://sid.ir/paper/309317/en

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