EFFECT OF VITAMIN C ON PARATHYROID HORMONE IN HEMODIALYSIS PATIENTS WITH MILD TO MODERATE SECONDARY HYPERPARATHYROIDISM

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SANADGOL HOUSHANG; BAYANI MAHTAB; MOHAMMADI MAHDI; BAYANI BAKTASH; MASHHADI MOHAMMAD ALI

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Journal: Iranian Journal of Kidney Diseases Year:2011 | Volume:5 | Issue:6 Page(s): 410-415

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Title

EFFECT OF VITAMIN C ON PARATHYROID HORMONE IN HEMODIALYSIS PATIENTS WITH MILD TO MODERATE SECONDARY HYPERPARATHYROIDISM

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Keywords

HEMODIALYSIS

PARATHYROID HORMONE

SECONDARY HYPERPARATHYROIDISM

ASCORBIC ACID

Abstract

Introduction: In end-stage renal disease, there is a high incidence of SECONDARY HYPERPARATHYROIDISM. It is proposed that increasing vitamin C levels by dietary supplementation results in a decrease of PARATHYROID HORMONE (PTH) in vitamin C-deficient HEMODIALYSIS patients with SECONDARY HYPERPARATHYROIDISM. The aim of this study was the evaluation of vitamin C administration for reduction of serum PTH level in HEMODIALYSIS patients.Materials and Methods: Twenty-one HEMODIALYSIS patients with serum PTH levels less than 550 pg/mL (but more than 200 pg/ mL) were administered intravenous vitamin C, 200 mg, 3 times per week for 3 months. Blood samples for measurement of PTH were obtained at the beginning of the HEMODIALYSIS session every month for three months.Results: The mean level of serum biointact PTH was 333.3±141.3 pg/mL (reference range, 7 pg/mL to 82 pg/mL) at baseline, and it decreased to 256.5±137.2 pg/mL at 1 month (P=0.03). The mean PTH level was also lower than the baseline value at 2 months (260.1±123.2 pg/mL, P=0.03), while it increased to 328.9±176.0 pg/mL at 3 months, which was still slightly lower than the baseline level (P=0.13). In 15 patients (71.4%), serum levels of PTH were lower than the baseline at months 1 to 2, while in the remaining 6 (28.6%), it was higher than the baseline value. At 3 months, 5 of the 15 patients with lower PTH levels up to the 3rd month experienced an increase in these levels again.Conclusions: Administration of intravenous vitamin C in HEMODIALYSIS patients noticeably decreased level of PTH, but its effect gradually diminished.

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APA: Copy

SANADGOL, HOUSHANG, BAYANI, MAHTAB, MOHAMMADI, MAHDI, BAYANI, BAKTASH, & MASHHADI, MOHAMMAD ALI. (2011). EFFECT OF VITAMIN C ON PARATHYROID HORMONE IN HEMODIALYSIS PATIENTS WITH MILD TO MODERATE SECONDARY HYPERPARATHYROIDISM. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 5(6), 410-415. SID. https://sid.ir/paper/309324/en

Vancouver: Copy

SANADGOL HOUSHANG, BAYANI MAHTAB, MOHAMMADI MAHDI, BAYANI BAKTASH, MASHHADI MOHAMMAD ALI. EFFECT OF VITAMIN C ON PARATHYROID HORMONE IN HEMODIALYSIS PATIENTS WITH MILD TO MODERATE SECONDARY HYPERPARATHYROIDISM. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2011;5(6):410-415. Available from: https://sid.ir/paper/309324/en

IEEE: Copy

HOUSHANG SANADGOL, MAHTAB BAYANI, MAHDI MOHAMMADI, BAKTASH BAYANI, and MOHAMMAD ALI MASHHADI, “EFFECT OF VITAMIN C ON PARATHYROID HORMONE IN HEMODIALYSIS PATIENTS WITH MILD TO MODERATE SECONDARY HYPERPARATHYROIDISM,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 5, no. 6, pp. 410–415, 2011, [Online]. Available: https://sid.ir/paper/309324/en

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