Changes in Kidney Function in a Population With Essential Hypertension in Real Life Settings

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Ptinopoulou Anastasia G.; Pikilidou Maria I.; Tziolas Ioannis M.; Haidich Anna Bettina; Mark Patrick B.; Zebekakis Pantelis E.; Lasaridis Anastasios N.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Kidney Diseases Year:2017 | Volume:11 | Issue:3 Page(s): 192-200

Download Full-Text

View:

315

Download:

122

Cites:

Information Journal Paper

Title

Changes in Kidney Function in a Population With Essential Hypertension in Real Life Settings

Author(s)

Keywords

antihypertensive drugs

blood pressure

chronic kidney disease

repeated measures analysis

mixed effects model

outpatient clinic

Abstract

Introduction. Hypertension has been identified as one of the commonest modifiable determinants for chronic kidney disease progression. A variety of antihypertensive drugs are available and their effect on kidney function has been investigated by a large number of randomized controlled trials. Observational studies, although scarcely been used, outpatient can reflect everyday practice, where drug exposures vary over time, and may provide an alternative for detecting longitudinal changes in kidney function. Materials and Methods. We applied mixed model repeated measures analysis to investigate the effect of antihypertensive drug categories and their combinations on kidney function change over time in a cohort of 779 patients with essential hypertension, using the data from a Greek hypertension outpatient clinic. antihypertensive drugs were grouped in 5 categories. Their effect was evaluated and their combinations with and without renin-angiotensin-system inhibitors (RASI) to each other. In addition, the combination of RASI with calcium channel blockers (CCBs) was studied. Results. Diuretics, RASI, CCBs, and beta-blockers had a significant renoprotective and blood pressure lowering effect. Combinations with RASI had a smaller beneficial effect on kidney function compared to CCBs (0. 75 mL/min/1. 73 m2 per year of drug use versus 0. 97 mL/min/1. 73 m2). There was no additional effect when combining RASI with CCBs. However, the lowering effect on systolic blood pressure was greater (-0. 83 mm Hg per year of drug use, P <. 001). Conclusions. RASI were found to have a smaller, although significant, renoprotective effect. There was no additional effect on kidney function when combining RASI with CCBs.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

APA: Copy

Ptinopoulou, Anastasia G., Pikilidou, Maria I., Tziolas, Ioannis M., Haidich, Anna Bettina, Mark, Patrick B., Zebekakis, Pantelis E., & Lasaridis, Anastasios N.. (2017). Changes in Kidney Function in a Population With Essential Hypertension in Real Life Settings. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 11(3), 192-200. SID. https://sid.ir/paper/309629/en

Vancouver: Copy

Ptinopoulou Anastasia G., Pikilidou Maria I., Tziolas Ioannis M., Haidich Anna Bettina, Mark Patrick B., Zebekakis Pantelis E., Lasaridis Anastasios N.. Changes in Kidney Function in a Population With Essential Hypertension in Real Life Settings. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2017;11(3):192-200. Available from: https://sid.ir/paper/309629/en

IEEE: Copy

Anastasia G. Ptinopoulou, Maria I. Pikilidou, Ioannis M. Tziolas, Anna Bettina Haidich, Patrick B. Mark, Pantelis E. Zebekakis, and Anastasios N. Lasaridis, “Changes in Kidney Function in a Population With Essential Hypertension in Real Life Settings,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 11, no. 3, pp. 192–200, 2017, [Online]. Available: https://sid.ir/paper/309629/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops